biostudies-literatureHuisman MNIBIB NIH HHSNational Institute of Biomedical Imaging and BioengineeringNational Science Foundation12590-12593https://www.ebi.ac.uk/biostudies/studies/S-EPMC5076553biostudies-literatureUnknown52(85)Photochemical control over irreversible inhibition was shown using Ru(ii)-caged inhibitors of cathepsin L. Levels of control were dependent on where the Ru(ii) complex was attached to the organic inhibitor, reaching >10 : 1 with optimal placement. A new strategy for photoreleasing Ru(ii) fragments from inhibitor-enzyme conjugates is also reported.Chemical communications (Cambridge, England)Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition.PMC5076553EB 016062R01 EB016072CHE-1465067Kodanko JJHuisman MPodgorski IWhite JKLewalski VGTurro CfalseCaging the uncageable: using metal complex release for photochemical control over irreversible inhibition.Photochemical control over irreversible inhibition was shown using Ru(ii)-caged inhibitors of cathepsin L. Levels of control were dependent on where the Ru(ii) complex was attached to the organic inhibitor, reaching >10 : 1 with optimal placement. A new strategy for photoreleasing Ru(ii) fragments from inhibitor-enzyme conjugates is also reported.2016-01-01T00:00:00Z2016 Oct2025-04-04T09:21:24.911Z2019-03-27T02:27:22ZS-EPMC50765532771134910.1039/c6cc07083c