biostudies-literatureChu EYNIDCR NIH HHSNIDDK NIH HHS1265-73https://www.ebi.ac.uk/biostudies/studies/S-EPMC5076757biostudies-literatureUnknown95(11)Clefting of the lip, with or without palatal involvement (CLP), is associated with a higher incidence of developmental tooth abnormalities, including hypodontia and supernumerary teeth, aberrant crown and root morphologies, and enamel defects, although the underlying mechanistic link is poorly understood. As most CLP genes are expressed throughout the oral epithelium, the authors hypothesized that the expression of CLP genes may persist in the dental epithelium and thus, in addition to their earlier role in labiopalatine development, may play an important functional role in subsequent tooth patterning and amelogenesis. To address this, the authors generated a unique conditional knockout model involving the major CLP gene, Irf6, that overcomes the previously reported perinatal lethality to Journal of dental researchFull Spectrum of Postnatal Tooth Phenotypes in a Novel Irf6 Cleft Lip Model.PMC5076757T32 DE007132R01 DE023177F30 DK100280Tamasas BSchutte BCCox TCChu EYFong HFoster BLSomerman MJTran ABMartin JFLaCourse MRfalseFull Spectrum of Postnatal Tooth Phenotypes in a Novel Irf6 Cleft Lip Model.Clefting of the lip, with or without palatal involvement (CLP), is associated with a higher incidence of developmental tooth abnormalities, including hypodontia and supernumerary teeth, aberrant crown and root morphologies, and enamel defects, although the underlying mechanistic link is poorly understood. As most CLP genes are expressed throughout the oral epithelium, the authors hypothesized that the expression of CLP genes may persist in the dental epithelium and thus, in addition to their earlier role in labiopalatine development, may play an important functional role in subsequent tooth patterning and amelogenesis. To address this, the authors generated a unique conditional knockout model involving the major CLP gene, Irf6, that overcomes the previously reported perinatal lethality to 2016-01-01T00:00:00Z2016 Oct2025-04-19T03:02:35.568Z2019-03-27T02:27:22ZS-EPMC50767572736958910.1177/0022034516656787