{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ranasinghe S"],"funding":["Quebec Health Research Fund","Beckman Young Investigator Program","Searle Scholars Program","Howard Hughes Medical Institute","NIAID NIH HHS","Ragon Institute","HHMI International Student Research Fellowship","NIAID","NIH","NIH/NIAID","NIH New Innovator Award","NSF Graduate Research Fellowship","Vir Bio, Inc.","NIGMS NIH HHS","Bill &amp; Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery"],"pagination":["917-930"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5077698"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(4)"],"pubmed_abstract":["CD8<sup>+</sup> T cell recognition of virus-infected cells is characteristically restricted by major histocompatibility complex (MHC) class I, although rare examples of MHC class II restriction have been reported in Cd4-deficient mice and a macaque SIV vaccine trial using a recombinant cytomegalovirus vector. Here, we demonstrate the presence of human leukocyte antigen (HLA) class II-restricted CD8<sup>+</sup> T cell responses with antiviral properties in a small subset of HIV-infected individuals. In these individuals, T cell receptor β (TCRβ) analysis revealed that class II-restricted CD8<sup>+</sup> T cells underwent clonal expansion and mediated killing of HIV-infected cells. In one case, these cells comprised 12% of circulating CD8<sup>+</sup> T cells, and TCRα analysis revealed two distinct co-expressed TCRα chains, with only one contributing to binding of the class II HLA-peptide complex. These data indicate that class II-restricted CD8<sup>+</sup> T cell responses can exist in a chronic human viral infection, and may contribute to immune control."],"journal":["Immunity"],"pubmed_title":["Antiviral CD8<sup>+</sup> T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion."],"pmcid":["PMC5077698"],"funding_grant_id":["U24 AI11862-01","P01 AI104715","P30 AI060354","AI104715","U24 AI118672","5P30AI060354","DP2 GM119419","R21 AI125085","DP2 OD020839","APP1108533"],"pubmed_authors":["Donaghey F","Walker BD","Kaufmann DE","White J","Clayton GM","Power K","Crawford F","Picker LJ","Ranasinghe S","Jani P","Kazer SW","Yosef N","Kappler JW","Allen TM","Shalek AK","Nwonu C","Streeck H","Soghoian DZ","Jones RB","Cole MB","Montoya A","Lamothe PA"],"additional_accession":[]},"is_claimable":false,"name":"Antiviral CD8<sup>+</sup> T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion.","description":"CD8<sup>+</sup> T cell recognition of virus-infected cells is characteristically restricted by major histocompatibility complex (MHC) class I, although rare examples of MHC class II restriction have been reported in Cd4-deficient mice and a macaque SIV vaccine trial using a recombinant cytomegalovirus vector. Here, we demonstrate the presence of human leukocyte antigen (HLA) class II-restricted CD8<sup>+</sup> T cell responses with antiviral properties in a small subset of HIV-infected individuals. In these individuals, T cell receptor β (TCRβ) analysis revealed that class II-restricted CD8<sup>+</sup> T cells underwent clonal expansion and mediated killing of HIV-infected cells. In one case, these cells comprised 12% of circulating CD8<sup>+</sup> T cells, and TCRα analysis revealed two distinct co-expressed TCRα chains, with only one contributing to binding of the class II HLA-peptide complex. These data indicate that class II-restricted CD8<sup>+</sup> T cell responses can exist in a chronic human viral infection, and may contribute to immune control.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Oct","modification":"2025-04-04T09:21:53.555Z","creation":"2019-03-27T02:27:24Z"},"accession":"S-EPMC5077698","cross_references":{"pubmed":["27760342"],"doi":["10.1016/j.immuni.2016.09.015"]}}