{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(22)"],"submitter":["Zhang XA"],"pubmed_abstract":["<h4>Background</h4>Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus named SFTS virus (SFTSV). We hypothesize that host genetic variations may contribute to susceptibility to SFTS.<h4>Results</h4>Compared with the rs1800818 AA genotype, AG + GG genotypes were significantly associated with increased susceptibility to SFTS (odds ratio, 1.66, 95% confidence interval = 1.28-2.16; P < 0.001). By using the ELISA assay, we observed that PDGF-BB concentration was significantly reduced in acute phase of patients than in the controls (P < 0.001) and recovered patients at 6 month (P = 0.007) and 12 month (P = 0.003). A persistently reduced PDGF-BB was also revealed from the SFTSV-infected C57BL/6J mice (P < 0.001). The rs1800818 G allele"],"journal":["Oncotarget"],"pagination":["33340-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5078099"],"repository":["biostudies-literature"],"pubmed_title":["The platelet derived growth factor-B polymorphism is associated with risk of severe fever with thrombocytopenia syndrome in Chinese individuals."],"pmcid":["PMC5078099"],"pubmed_authors":["Huang DD","Cui N","Peng W","Hu CY","Cao WC","Yang ZD","Zhang XA","Liu R","Ding SJ","Lu QB","Wang XJ","Liu W","Qin SL","Guo CT","Hu JG"],"additional_accession":[]},"is_claimable":false,"name":"The platelet derived growth factor-B polymorphism is associated with risk of severe fever with thrombocytopenia syndrome in Chinese individuals.","description":"<h4>Background</h4>Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus named SFTS virus (SFTSV). We hypothesize that host genetic variations may contribute to susceptibility to SFTS.<h4>Results</h4>Compared with the rs1800818 AA genotype, AG + GG genotypes were significantly associated with increased susceptibility to SFTS (odds ratio, 1.66, 95% confidence interval = 1.28-2.16; P < 0.001). By using the ELISA assay, we observed that PDGF-BB concentration was significantly reduced in acute phase of patients than in the controls (P < 0.001) and recovered patients at 6 month (P = 0.007) and 12 month (P = 0.003). A persistently reduced PDGF-BB was also revealed from the SFTSV-infected C57BL/6J mice (P < 0.001). The rs1800818 G allele","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2026-04-17T11:22:51.572Z","creation":"2025-05-29T19:42:46.399Z"},"accession":"S-EPMC5078099","cross_references":{"pubmed":["27147565"],"doi":["10.18632/oncotarget.9043"]}}