biostudies-literatureZarrinpar ANIDDK NIH HHSNCI NIH HHS69-83https://www.ebi.ac.uk/biostudies/studies/S-EPMC5081399biostudies-literatureUnknown27(2)Cyclical expression of cell-autonomous circadian clock components and key metabolic regulators coordinate often discordant and distant cellular processes for efficient metabolism. Perturbation of these cycles, either by genetic manipulation, disruption of light/dark cycles, or, most relevant to the human population, via eating patterns, contributes to obesity and dysmetabolism. Time-restricted feeding (TRF), during which time of access to food is restricted to a few hours, without caloric restriction, supports robust metabolic cycles and protects against nutritional challenges that predispose to obesity and dysmetabolism. The mechanism by which TRF imparts its benefits is not fully understood but likely involves entrainment of metabolically active organs through gut signaling. Understanding the relationship of feeding pattern and metabolism could yield novel therapies for the obesity pandemic.Trends in endocrinology and metabolism: TEMDaily Eating Patterns and Their Impact on Health and Disease.PMC5081399R01 DK091618K08 DK102902P30 CA014195T32 DK007202DK091618Zarrinpar APanda SChaix AfalseDaily Eating Patterns and Their Impact on Health and Disease.Cyclical expression of cell-autonomous circadian clock components and key metabolic regulators coordinate often discordant and distant cellular processes for efficient metabolism. Perturbation of these cycles, either by genetic manipulation, disruption of light/dark cycles, or, most relevant to the human population, via eating patterns, contributes to obesity and dysmetabolism. Time-restricted feeding (TRF), during which time of access to food is restricted to a few hours, without caloric restriction, supports robust metabolic cycles and protects against nutritional challenges that predispose to obesity and dysmetabolism. The mechanism by which TRF imparts its benefits is not fully understood but likely involves entrainment of metabolically active organs through gut signaling. Understanding the relationship of feeding pattern and metabolism could yield novel therapies for the obesity pandemic.2016-01-01T00:00:00Z2016 Feb2025-04-22T06:59:50.704Z2019-03-27T02:27:35ZS-EPMC50813992670656710.1016/j.tem.2015.11.007