biostudies-literatureLacret RSeventh Framework ProgrammeE188https://www.ebi.ac.uk/biostudies/studies/S-EPMC5082336biostudies-literatureUnknown14(10)A new napyradiomycin, MDN-0170 (1), was isolated from the culture broth of the marine-derived actinomycete strain CA-271078, together with three known related compounds identified as 4-dehydro-4a-dechloronapyradiomycin A1 (2), napyradiomycin A1 (3) and 3-chloro-6,8-dihydroxy-8-α-lapachone (4). The structure of the new compound was determined using a combination of spectroscopic techniques, including 1D and 2D NMR and electrospray-time of flight mass spectrometry (ESI-TOF MS). The relative configuration of compound 1, which contains two independent stereoclusters, has been established by molecular modelling in combination with nOe and coupling constant analyses. Biosynthetic arguments also allowed us to propose its absolute stereochemistry. The antimicrobial properties of the compounds isolMarine drugsMDN-0170, a New Napyradiomycin from Streptomyces sp. Strain CA-271078.PMC5082336312184Domingo EMartin Jde la Cruz MOves-Costales DReyes FPerez-Victoria IGenilloud OLacret RDiaz CVicente FfalseMDN-0170, a New Napyradiomycin from Streptomyces sp. Strain CA-271078.A new napyradiomycin, MDN-0170 (1), was isolated from the culture broth of the marine-derived actinomycete strain CA-271078, together with three known related compounds identified as 4-dehydro-4a-dechloronapyradiomycin A1 (2), napyradiomycin A1 (3) and 3-chloro-6,8-dihydroxy-8-α-lapachone (4). The structure of the new compound was determined using a combination of spectroscopic techniques, including 1D and 2D NMR and electrospray-time of flight mass spectrometry (ESI-TOF MS). The relative configuration of compound 1, which contains two independent stereoclusters, has been established by molecular modelling in combination with nOe and coupling constant analyses. Biosynthetic arguments also allowed us to propose its absolute stereochemistry. The antimicrobial properties of the compounds isol2016-01-01T00:00:00Z2016 Oct2025-04-27T01:59:12.538Z2019-03-27T02:27:38ZS-EPMC50823362776354510.3390/md14100188