{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kaz AM"],"funding":["NIDDK NIH HHS","National Institute of Health","NCI NIH HHS","Mercer Island Rotary Club","National Institutes of Health","Listwin Family Foundation"],"pagination":["111"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5082363"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["<h4>Background</h4>The risk of developing Barrett's esophagus (BE) and/or esophageal adenocarcinoma (EAC) is associated with specific demographic and behavioral factors, including gender, obesity/elevated body mass index (BMI), and tobacco use. Alterations in DNA methylation, an epigenetic modification that can affect gene expression and that can be influenced by environmental factors, is frequently present in both BE and EAC and is believed to play a role in the formation of BE and its progression to EAC. It is currently unknown whether obesity or tobacco smoking influences the risk of developing BE/EAC via the induction of alterations in DNA methylation. To investigate this possibility, we assessed the genome-wide methylation status of 81 esophageal tissues, including BE, dysplastic BE, "],"journal":["Clinical epigenetics"],"pubmed_title":["Global DNA methylation patterns in Barrett's esophagus, dysplastic Barrett's, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use."],"pmcid":["PMC5082363"],"funding_grant_id":["U54CA163060","U01 CA086402","U01CA182940","U01 CA182940","P30 CA015704","P30 DK097948","P50CA150964","T32 CA094186","U54 CA163060","P50 CA150964","U01 CA152756"],"pubmed_authors":["Kaz AM","Wong CJ","Grady WM","Varadan V","Willis JE","Chak A"],"additional_accession":[]},"is_claimable":false,"name":"Global DNA methylation patterns in Barrett's esophagus, dysplastic Barrett's, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use.","description":"<h4>Background</h4>The risk of developing Barrett's esophagus (BE) and/or esophageal adenocarcinoma (EAC) is associated with specific demographic and behavioral factors, including gender, obesity/elevated body mass index (BMI), and tobacco use. Alterations in DNA methylation, an epigenetic modification that can affect gene expression and that can be influenced by environmental factors, is frequently present in both BE and EAC and is believed to play a role in the formation of BE and its progression to EAC. It is currently unknown whether obesity or tobacco smoking influences the risk of developing BE/EAC via the induction of alterations in DNA methylation. To investigate this possibility, we assessed the genome-wide methylation status of 81 esophageal tissues, including BE, dysplastic BE, ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2026-07-15T16:29:46.979Z","creation":"2026-07-07T03:08:18.407Z"},"accession":"S-EPMC5082363","cross_references":{"pubmed":["27795744"],"doi":["10.1186/s13148-016-0273-7"]}}