{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Connell BJ"],"funding":["Austrian Science Fund FWF","National Science Council","Agence Nationale de Recherches sur le Sida et les Hepatites Virales","Agence Nationale de la Recherche","Sidaction"],"pagination":["e0165386"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5082894"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(10)"],"pubmed_abstract":["Amongst the many strategies aiming at inhibiting HIV-1 infection, blocking viral entry has been recently recognized as a very promising approach. Using diverse in vitro models and a broad range of HIV-1 primary patient isolates, we report here that IND02, a type A procyanidin polyphenol extracted from cinnamon, that features trimeric and pentameric forms displays an anti-HIV-1 activity against CXCR4 and CCR5 viruses with 1-7 μM ED50 for the trimer. Competition experiments, using a surface plasmon resonance-based binding assay, revealed that IND02 inhibited envelope binding to CD4 and heparan sulphate (HS) as well as to an antibody (mAb 17b) directed against the gp120 co-receptor binding site with an IC50 in the low μM range. IND02 has thus the remarkable property of simultaneously blocking"],"journal":["PloS one"],"pubmed_title":["A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation."],"pmcid":["PMC5082894"],"funding_grant_id":["P 25389"],"pubmed_authors":["Kodama EN","Prakash E","Mohan V","Wilflingseder D","Moog C","Chang SY","Lortat-Jacob H","Clayette P","Yousfi R","Connell BJ","Posch W"],"additional_accession":[]},"is_claimable":false,"name":"A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation.","description":"Amongst the many strategies aiming at inhibiting HIV-1 infection, blocking viral entry has been recently recognized as a very promising approach. Using diverse in vitro models and a broad range of HIV-1 primary patient isolates, we report here that IND02, a type A procyanidin polyphenol extracted from cinnamon, that features trimeric and pentameric forms displays an anti-HIV-1 activity against CXCR4 and CCR5 viruses with 1-7 μM ED50 for the trimer. Competition experiments, using a surface plasmon resonance-based binding assay, revealed that IND02 inhibited envelope binding to CD4 and heparan sulphate (HS) as well as to an antibody (mAb 17b) directed against the gp120 co-receptor binding site with an IC50 in the low μM range. IND02 has thus the remarkable property of simultaneously blocking","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-04-27T01:57:21.364Z","creation":"2019-03-26T22:48:38Z"},"accession":"S-EPMC5082894","cross_references":{"pubmed":["27788205"],"doi":["10.1371/journal.pone.0165386"]}}