{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Massimo L"],"funding":["NIA NIH HHS","NINR NIH HHS"],"pagination":["574-581"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5083230"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(5)"],"pubmed_abstract":["OBJECTIVE:To determine (1) whether delirium severity was associated with Apolipoprotein E (APOE) genotype status and occupational complexity, a measure of cognitive reserve, in individuals with delirium superimposed on dementia; and (2) whether decline in delirium severity was associated with these same factors over a post-acute care (PAC) stay. METHODS:Control group data (n?=?142) from a completed randomized clinical trial were used to address the aims of the study. Delirium severity was calculated by combining items from the Confusion Assessment Method and the Montreal Cognitive Assessment. APOE ?4 carriers versus non-carriers were considered. Occupational complexity, a measure of cognitive reserve, was derived from the Lifetime of Experiences Questionnaire. Covariates examined included age, gender, education, Clinical Dementia Rating Scale, and the Charlson comorbidity score. Data were nested (i.e., days nested within persons) and analyzed using multilevel models. RESULTS:The presence of an APOE ?4 allele and higher Clinical Dementia Rating Scale were associated with greater delirium severity at baseline. The presence of an APOE ?4 allele was also associated with greater delirium severity averaged across the PAC stay. Occupational complexity was not associated with baseline delirium severity or average daily delirium severity; however, individuals with low occupational complexity showed a significant decreased in delirium severity during the course of their PAC stay. CONCLUSIONS:Individual differences, including genetic factors and level of cognitive reserve, contribute to the severity of delirium in older adults with dementia. Copyright © 2016 John Wiley & Sons, Ltd."],"journal":["International journal of geriatric psychiatry"],"pubmed_title":["Genetic and environmental factors associated with delirium severity in older adults with dementia."],"pmcid":["PMC5083230"],"funding_grant_id":["R01 NR012242","F32 NR014777","K99 AG056054","K01 AG043503","P01 AG017586"],"pubmed_authors":["McMillan CT","Vandenbergh D","Fick D","Hill N","Mulhall P","Clare L","Kolanowski A","Massimo L","Munoz E","Mogle J"],"additional_accession":[]},"is_claimable":false,"name":"Genetic and environmental factors associated with delirium severity in older adults with dementia.","description":"OBJECTIVE:To determine (1) whether delirium severity was associated with Apolipoprotein E (APOE) genotype status and occupational complexity, a measure of cognitive reserve, in individuals with delirium superimposed on dementia; and (2) whether decline in delirium severity was associated with these same factors over a post-acute care (PAC) stay. METHODS:Control group data (n?=?142) from a completed randomized clinical trial were used to address the aims of the study. Delirium severity was calculated by combining items from the Confusion Assessment Method and the Montreal Cognitive Assessment. APOE ?4 carriers versus non-carriers were considered. Occupational complexity, a measure of cognitive reserve, was derived from the Lifetime of Experiences Questionnaire. Covariates examined included age, gender, education, Clinical Dementia Rating Scale, and the Charlson comorbidity score. Data were nested (i.e., days nested within persons) and analyzed using multilevel models. RESULTS:The presence of an APOE ?4 allele and higher Clinical Dementia Rating Scale were associated with greater delirium severity at baseline. The presence of an APOE ?4 allele was also associated with greater delirium severity averaged across the PAC stay. Occupational complexity was not associated with baseline delirium severity or average daily delirium severity; however, individuals with low occupational complexity showed a significant decreased in delirium severity during the course of their PAC stay. CONCLUSIONS:Individual differences, including genetic factors and level of cognitive reserve, contribute to the severity of delirium in older adults with dementia. Copyright © 2016 John Wiley & Sons, Ltd.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 May","modification":"2020-11-19T15:41:52Z","creation":"2019-06-06T16:33:01Z"},"accession":"S-EPMC5083230","cross_references":{"pubmed":["27122004"],"doi":["10.1002/gps.4496"]}}