{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Leaf DE"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS"],"pagination":["3291-3297"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5084897"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(11)"],"pubmed_abstract":["Heme oxygenase-1 (HO-1) catalyzes the degradation of heme, which may be involved in the pathogenesis of AKI. Length polymorphisms in the number of GT dinucleotide repeats in the HO-1 gene (HMOX1) promoter inversely associate with HMOX1 mRNA expression. We analyzed the association between allelic frequencies of GT repeats in the HMOX1 gene promoter and postoperative AKI in 2377 white patients who underwent cardiac surgery with cardiopulmonary bypass. We categorized patients as having the short allele (S; <27 GT repeats) or long allele (L; ≥27 GT repeats), and defined AKI as an increase in serum creatinine ≥0.3 mg/dl within 48 hours or ≥50% within 5 days, or the need for RRT. Compared with patients with the SS genotype, patients with the LL genotype had 1.58-fold (95% confidence interval, 1.06 to 2.34; P=0.02) higher odds of AKI. After adjusting for baseline and operative characteristics, the odds ratio for AKI per L allele was 1.26 (95% confidence interval, 1.05 to 1.50; P=0.01). In conclusion, longer GT repeats in the HMOX1 gene promoter associate with increased risk of AKI after cardiac surgery, consistent with heme toxicity as a pathogenic feature of cardiac surgery-associated AKI, and with HO-1 as a potential therapeutic target."],"journal":["Journal of the American Society of Nephrology : JASN"],"pubmed_title":["Length Polymorphisms in Heme Oxygenase-1 and AKI after Cardiac Surgery."],"pmcid":["PMC5084897"],"funding_grant_id":["R01 DK093574","U01 DK104308","R01 HL098601","R01 DK103784","R01 HL118266","U01 DK085660","K23 DK106448","P30 DK079337"],"pubmed_authors":["Muehlschlegel JD","Waikar SS","McMahon GM","Lichtner P","Body SC","Collard CD","Shernan SK","Fox AA","Leaf DE"],"additional_accession":[]},"is_claimable":false,"name":"Length Polymorphisms in Heme Oxygenase-1 and AKI after Cardiac Surgery.","description":"Heme oxygenase-1 (HO-1) catalyzes the degradation of heme, which may be involved in the pathogenesis of AKI. Length polymorphisms in the number of GT dinucleotide repeats in the HO-1 gene (HMOX1) promoter inversely associate with HMOX1 mRNA expression. We analyzed the association between allelic frequencies of GT repeats in the HMOX1 gene promoter and postoperative AKI in 2377 white patients who underwent cardiac surgery with cardiopulmonary bypass. We categorized patients as having the short allele (S; <27 GT repeats) or long allele (L; ≥27 GT repeats), and defined AKI as an increase in serum creatinine ≥0.3 mg/dl within 48 hours or ≥50% within 5 days, or the need for RRT. Compared with patients with the SS genotype, patients with the LL genotype had 1.58-fold (95% confidence interval, 1.06 to 2.34; P=0.02) higher odds of AKI. After adjusting for baseline and operative characteristics, the odds ratio for AKI per L allele was 1.26 (95% confidence interval, 1.05 to 1.50; P=0.01). In conclusion, longer GT repeats in the HMOX1 gene promoter associate with increased risk of AKI after cardiac surgery, consistent with heme toxicity as a pathogenic feature of cardiac surgery-associated AKI, and with HO-1 as a potential therapeutic target.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Nov","modification":"2025-04-18T20:49:56.275Z","creation":"2019-03-27T02:27:46Z"},"accession":"S-EPMC5084897","cross_references":{"pubmed":["27257045"],"doi":["10.1681/asn.2016010038","10.1681/ASN.2016010038"]}}