{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma H"],"funding":["National Natural Science Foundation of China"],"pagination":["E969"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5086708"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(10)"],"pubmed_abstract":["The antioxidant properties of l-arginine (l-Arg) in vivo, and its effect on enhancing resistance to oxidative stress and heat stress in Caenorhabditis elegans were investigated. C. elegans, a worm model popularly used in molecular and developmental biology, was used in the present study. Here, we report that l-Arg, at a concentration of 1 mM, prolonged C. elegans life by 26.98% and 37.02% under oxidative and heat stress, respectively. Further experiments indicated that the longevity-extending effects of l-Arg may be exerted by its free radical scavenging capacity and the upregulation of aging-associated gene expression in worms. This work is important in the context of numerous recent studies that concluded that environment stresses are associated with an increased population death rate."],"journal":["International journal of environmental research and public health"],"pubmed_title":["l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans."],"pmcid":["PMC5086708"],"funding_grant_id":["81571791, 31571017, 81271697"],"pubmed_authors":["Xu L","Lin R","Zhu J","Zhang Z","Guo Y","Ma H","Ma Y","Zhao Z"],"additional_accession":[]},"is_claimable":false,"name":"l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans.","description":"The antioxidant properties of l-arginine (l-Arg) in vivo, and its effect on enhancing resistance to oxidative stress and heat stress in Caenorhabditis elegans were investigated. C. elegans, a worm model popularly used in molecular and developmental biology, was used in the present study. Here, we report that l-Arg, at a concentration of 1 mM, prolonged C. elegans life by 26.98% and 37.02% under oxidative and heat stress, respectively. Further experiments indicated that the longevity-extending effects of l-Arg may be exerted by its free radical scavenging capacity and the upregulation of aging-associated gene expression in worms. This work is important in the context of numerous recent studies that concluded that environment stresses are associated with an increased population death rate.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Sep","modification":"2025-04-26T15:06:52.82Z","creation":"2019-03-27T02:27:51Z"},"accession":"S-EPMC5086708","cross_references":{"pubmed":["27690079"],"doi":["10.3390/ijerph13100969"]}}