biostudies-literatureMa HNational Natural Science Foundation of ChinaE969https://www.ebi.ac.uk/biostudies/studies/S-EPMC5086708biostudies-literatureUnknown13(10)The antioxidant properties of l-arginine (l-Arg) in vivo, and its effect on enhancing resistance to oxidative stress and heat stress in Caenorhabditis elegans were investigated. C. elegans, a worm model popularly used in molecular and developmental biology, was used in the present study. Here, we report that l-Arg, at a concentration of 1 mM, prolonged C. elegans life by 26.98% and 37.02% under oxidative and heat stress, respectively. Further experiments indicated that the longevity-extending effects of l-Arg may be exerted by its free radical scavenging capacity and the upregulation of aging-associated gene expression in worms. This work is important in the context of numerous recent studies that concluded that environment stresses are associated with an increased population death rate.International journal of environmental research and public healthl-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans.PMC508670881571791, 31571017, 81271697Xu LLin RZhu JZhang ZGuo YMa HMa YZhao Zfalsel-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans.The antioxidant properties of l-arginine (l-Arg) in vivo, and its effect on enhancing resistance to oxidative stress and heat stress in Caenorhabditis elegans were investigated. C. elegans, a worm model popularly used in molecular and developmental biology, was used in the present study. Here, we report that l-Arg, at a concentration of 1 mM, prolonged C. elegans life by 26.98% and 37.02% under oxidative and heat stress, respectively. Further experiments indicated that the longevity-extending effects of l-Arg may be exerted by its free radical scavenging capacity and the upregulation of aging-associated gene expression in worms. This work is important in the context of numerous recent studies that concluded that environment stresses are associated with an increased population death rate.2016-01-01T00:00:00Z2016 Sep2025-04-26T15:06:52.82Z2019-03-27T02:27:51ZS-EPMC50867082769007910.3390/ijerph13100969