biostudies-literatureHuang HNational Cancer InstituteNCI NIH HHSNational Institute of General Medical SciencesNIGMS NIH HHS23208-23223https://www.ebi.ac.uk/biostudies/studies/S-EPMC5087738biostudies-literatureUnknown291(44)Pancreatic ductal adenocarcinomas are highly malignant cancers characterized by extensive invasion into surrounding tissues, metastasis to distant organs, and a limited response to therapy. A main feature of pancreatic ductal adenocarcinomas is desmoplasia, which leads to extensive deposition of collagen I. We have demonstrated that collagen I can induce epithelial-mesenchymal transition (EMT) in pancreatic cancer cells. A hallmark of EMT is an increase in the expression of the mesenchymal cadherin N-cadherin. Previously we showed up-regulation of N-cadherin promotes tumor cell invasion and that collagen I-induced EMT is mediated by two collagen receptors, α2β1-integrin and discoidin domain receptor 1 (DDR1). DDR1 is a receptor-tyrosine kinase widely expressed during embryonic development The Journal of biological chemistryUp-regulation of N-cadherin by Collagen I-activated Discoidin Domain Receptor 1 in Pancreatic Cancer Requires the Adaptor Molecule Shc1.PMC5087738P30 CA036727U01 CA111294R01GM051188P50 CA127297P30 GM106397U01CA111294U54CA163120R21CA137401U54 CA163120R21 CA137401P30CA036727R01 GM051188P30GM1063970P50CA127297Lazenby AJWheelock MJHuang HSaowapa JChaika NJohnson KRDing KSvoboda RAfalseUp-regulation of N-cadherin by Collagen I-activated Discoidin Domain Receptor 1 in Pancreatic Cancer Requires the Adaptor Molecule Shc1.Pancreatic ductal adenocarcinomas are highly malignant cancers characterized by extensive invasion into surrounding tissues, metastasis to distant organs, and a limited response to therapy. A main feature of pancreatic ductal adenocarcinomas is desmoplasia, which leads to extensive deposition of collagen I. We have demonstrated that collagen I can induce epithelial-mesenchymal transition (EMT) in pancreatic cancer cells. A hallmark of EMT is an increase in the expression of the mesenchymal cadherin N-cadherin. Previously we showed up-regulation of N-cadherin promotes tumor cell invasion and that collagen I-induced EMT is mediated by two collagen receptors, α2β1-integrin and discoidin domain receptor 1 (DDR1). DDR1 is a receptor-tyrosine kinase widely expressed during embryonic development 2016-01-01T00:00:00Z2016 Oct2025-04-04T14:57:46.158Z2019-03-27T02:27:53ZS-EPMC50877382760566810.1074/jbc.m116.74060510.1074/jbc.M116.740605