biostudies-literatureMartinon-Torres FMedical Research FoundationMRF_Wellcome Trust35842https://www.ebi.ac.uk/biostudies/studies/S-EPMC5090968biostudies-literatureUnknown6Meningococcal disease (MD) remains an important infectious cause of life threatening infection in both industrialized and resource poor countries. Genetic factors influence both occurrence and severity of presentation, but the genes responsible are largely unknown. We performed a genome-wide association study (GWAS) examining 5,440,063 SNPs in 422 Spanish MD patients and 910 controls. We then performed a meta-analysis of the Spanish GWAS with GWAS data from the United Kingdom (combined cohorts: 897 cases and 5,613 controls; 4,898,259 SNPs). The meta-analysis identified strong evidence of association (P-value ≤ 5 × 10^-8) in 20 variants located at the CFH gene. SNP rs193053835 showed the most significant protective effect (Odds Ratio (OR) = 0.62, 95% confidence interval (C.I.) = 0Scientific reportsNatural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies.PMC5090968085475C0483Munoz Bonet JISancho-Shimizu VSanchez Granados JMPollard AJHoggart CAlonso Martin JAIturbe EBRosso SPPathan NHabibi PDavila Sde Aguilar PAAlonso SMOrtega ACBergara EOMartinez-Padilla MDPalazon SCWright VJGarzon MGCarracedo ATorne EEGarcia SRBarral-Arca RCebey Mde la Cruz Moreno JKroll SFachal LMartinon-Torres NRodriguez-Tenreiro CHibberd MLRomero ARCancela MSSanchez NGAbdulla FMartinon-Torres FHaralambous EPardo-Seco JAgapow PFernandez MSSanchez FGESIGEM networkMenchon NMFernandez IQVillanueba DALangford PMashbat MLeon Leon MCHamilton SVega ACaballero Macarron CPPayo RGomez-Carballa AMorteruel EGrande AJMartinon-Sanchez JMAlonso Salas MTCarrol EDCalle IRDominguez SRPischedda SHerberg JAInwald DNadel SSanchez FPMillan Miralles MLKaforou MSalas ACurras-Tuala MJKhor CCArriortua ABGarcia Rodriguez JLPallares MOEleftherohorinou HMustafa SGarcia MDRedondo-Collazo LCoin LJDoce AHNavarro Gomez MLSim KSTorre ACMonge CCLevin MEUCLIDS consortium members - Imperial College London (www.euclids-project.eu)Faust SGalassini RMartinez XAPng EBarba AFBellos EAyestaran OSBooy RESPID meningococcal consortium – UKLopez-Bayon JOrayen CGfalseNatural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies.Meningococcal disease (MD) remains an important infectious cause of life threatening infection in both industrialized and resource poor countries. Genetic factors influence both occurrence and severity of presentation, but the genes responsible are largely unknown. We performed a genome-wide association study (GWAS) examining 5,440,063 SNPs in 422 Spanish MD patients and 910 controls. We then performed a meta-analysis of the Spanish GWAS with GWAS data from the United Kingdom (combined cohorts: 897 cases and 5,613 controls; 4,898,259 SNPs). The meta-analysis identified strong evidence of association (P-value ≤ 5 × 10^-8) in 20 variants located at the CFH gene. SNP rs193053835 showed the most significant protective effect (Odds Ratio (OR) = 0.62, 95% confidence interval (C.I.) = 02016-01-01T00:00:00Z2016 Nov2026-05-01T01:54:10.327Z2019-03-27T02:28:02ZS-EPMC50909682780504610.1038/srep35842