{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yan H"],"funding":["National Natural Science Foundation of China"],"pagination":["1786"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5099522"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7"],"pubmed_abstract":["Increased evidences have demonstrated that gut microbiota targeted diet intervention can alleviate obesity and related metabolic disorders. The underlying mechanism of interactions among diet, microbiota, and host still remains unclear. <i>Enterobacter cloacae</i> B29, an endotoxin-producing strain dominated in the gut of a morbidly obese volunteer (weight 174.8 kg, BMI 58.8 kg m<sup>-2</sup>) was isolated and transplanted to germfree mice (inoculated 10<sup>10</sup> cells of B29 per day for 1 week). Using deep mRNA sequencing technology, we compared different gene expression profiles in the colon samples of the germfree mice treated with/without B29 and/or high fat diet (HFD) for 16 weeks and identified 279 differential expressed genes in total, including up-regulated genes <i>Apoa4</i> ("],"journal":["Frontiers in microbiology"],"pubmed_title":["Regulated Inflammation and Lipid Metabolism in Colon mRNA Expressions of Obese Germfree Mice Responding to <i>Enterobacter cloacae</i> B29 Combined with the High Fat Diet."],"pmcid":["PMC5099522"],"funding_grant_id":["31330005, 20875061"],"pubmed_authors":["Fei N","Zhao L","Zhang M","Wu G","Zhang C","Yan H"],"additional_accession":[]},"is_claimable":false,"name":"Regulated Inflammation and Lipid Metabolism in Colon mRNA Expressions of Obese Germfree Mice Responding to <i>Enterobacter cloacae</i> B29 Combined with the High Fat Diet.","description":"Increased evidences have demonstrated that gut microbiota targeted diet intervention can alleviate obesity and related metabolic disorders. The underlying mechanism of interactions among diet, microbiota, and host still remains unclear. <i>Enterobacter cloacae</i> B29, an endotoxin-producing strain dominated in the gut of a morbidly obese volunteer (weight 174.8 kg, BMI 58.8 kg m<sup>-2</sup>) was isolated and transplanted to germfree mice (inoculated 10<sup>10</sup> cells of B29 per day for 1 week). Using deep mRNA sequencing technology, we compared different gene expression profiles in the colon samples of the germfree mice treated with/without B29 and/or high fat diet (HFD) for 16 weeks and identified 279 differential expressed genes in total, including up-regulated genes <i>Apoa4</i> (","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2026-04-07T15:46:31.478Z","creation":"2019-03-27T02:28:29Z"},"accession":"S-EPMC5099522","cross_references":{"pubmed":["27877172"],"doi":["10.3389/fmicb.2016.01786"]}}