{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Ohgami N"],"pubmed_abstract":["Despite the fact that manganese (Mn) is known to be a neurotoxic element relevant to age-related disorders, the risk of oral exposure to Mn for age-related hearing loss remains unclear. In this study, we orally exposed wild-type young adult mice to Mn (Mn-exposed WT-mice) at 1.65 and 16.50 mg/L for 4 weeks. Mn-exposed WT-mice showed acceleration of age-related hearing loss. Mn-exposed WT-mice had neurodegeneration of spiral ganglion neurons (SGNs) with increased number of lipofuscin granules. Mn-exposed WT-mice also had increased hypoxia-inducible factor-1 alpha (Hif-1α) protein with less hydroxylation at proline 564 and decreased c-Ret protein in SGNs. Mn-mediated acceleration of age-related hearing loss involving neurodegeneration of SGNs was rescued in RET-transgenic mice carrying const"],"journal":["Scientific reports"],"pagination":["36306"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5099889"],"repository":["biostudies-literature"],"pubmed_title":["Manganese-mediated acceleration of age-related hearing loss in mice."],"pmcid":["PMC5099889"],"pubmed_authors":["Li X","Iida M","Kumasaka MY","Oshino R","Yajima I","Kato M","Ohgami N"],"additional_accession":[]},"is_claimable":false,"name":"Manganese-mediated acceleration of age-related hearing loss in mice.","description":"Despite the fact that manganese (Mn) is known to be a neurotoxic element relevant to age-related disorders, the risk of oral exposure to Mn for age-related hearing loss remains unclear. In this study, we orally exposed wild-type young adult mice to Mn (Mn-exposed WT-mice) at 1.65 and 16.50 mg/L for 4 weeks. Mn-exposed WT-mice showed acceleration of age-related hearing loss. Mn-exposed WT-mice had neurodegeneration of spiral ganglion neurons (SGNs) with increased number of lipofuscin granules. Mn-exposed WT-mice also had increased hypoxia-inducible factor-1 alpha (Hif-1α) protein with less hydroxylation at proline 564 and decreased c-Ret protein in SGNs. Mn-mediated acceleration of age-related hearing loss involving neurodegeneration of SGNs was rescued in RET-transgenic mice carrying const","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Nov","modification":"2025-04-18T18:35:26.985Z","creation":"2019-03-27T02:28:30Z"},"accession":"S-EPMC5099889","cross_references":{"pubmed":["27824154"],"doi":["10.1038/srep36306"]}}