biostudies-literatureCrook MNIGMS NIH HHS3533-3540https://www.ebi.ac.uk/biostudies/studies/S-EPMC5100852biostudies-literatureUnknown6(11)Identification of pro-cell survival signaling pathways has implications for cancer, cardiovascular, and neurodegenerative disease. We show that the <i>Caenorhabditis elegans</i> epidermal growth factor receptor LET-23 (LET-23 EGFR) has a prosurvival function in counteracting excitotoxicity, and we identify novel molecular players required for this prosurvival signaling. uv1 sensory cells in the <i>C. elegans</i> uterus undergo excitotoxic death in response to activation of the OSM-9/OCR-4 TRPV channel by the endogenous agonist nicotinamide. Activation of LET-23 EGFR can effectively prevent this excitotoxic death. We investigate the roles of signaling pathways known to act downstream of LET-23 EGFR in <i>C. elegans</i> and find that the LET-60 Ras/MAPK pathway, but not the IP₃ reG3 (Bethesda, Md.)Epidermal Growth Factor Receptor Cell Survival Signaling Requires Phosphatidylcholine Biosynthesis.PMC5100852R01 GM086786Crook MHanna-Rose WUpadhyay AIdo LJfalseEpidermal Growth Factor Receptor Cell Survival Signaling Requires Phosphatidylcholine Biosynthesis.Identification of pro-cell survival signaling pathways has implications for cancer, cardiovascular, and neurodegenerative disease. We show that the <i>Caenorhabditis elegans</i> epidermal growth factor receptor LET-23 (LET-23 EGFR) has a prosurvival function in counteracting excitotoxicity, and we identify novel molecular players required for this prosurvival signaling. uv1 sensory cells in the <i>C. elegans</i> uterus undergo excitotoxic death in response to activation of the OSM-9/OCR-4 TRPV channel by the endogenous agonist nicotinamide. Activation of LET-23 EGFR can effectively prevent this excitotoxic death. We investigate the roles of signaling pathways known to act downstream of LET-23 EGFR in <i>C. elegans</i> and find that the LET-60 Ras/MAPK pathway, but not the IP₃ re2016-01-01T00:00:00Z2016 Nov2025-04-22T08:57:31.801Z2019-03-27T02:28:34ZS-EPMC51008522760551910.1534/g3.116.034850