{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Komura D"],"funding":["Japan Agency for Medical Research and Development","Tokyo Medical and Dental University","Japan Society for the Promotion of Science"],"pagination":["899"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5103609"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["<h4>Background</h4>Cancer microenvironment plays a vital role in cancer development and progression, and cancer-stromal interactions have been recognized as important targets for cancer therapy. However, identifying relevant and druggable cancer-stromal interactions is challenging due to the lack of quantitative methods to analyze whole cancer-stromal interactome.<h4>Results</h4>We present CASTIN (CAncer-STromal INteractome analysis), a novel framework for the evaluation of cancer-stromal interactome from RNA-Seq data using cancer xenograft models. For each ligand-receptor interaction which is derived from curated protein-protein interaction database, CASTIN summarizes gene expression profiles of cancer and stroma into three evaluation indices. These indices provide quantitative evaluation"],"journal":["BMC genomics"],"pubmed_title":["CASTIN: a system for comprehensive analysis of cancer-stromal interactome."],"pmcid":["PMC5103609"],"funding_grant_id":["4K112","15H04287","16H02481"],"pubmed_authors":["Suzuki R","Ishikawa S","Kishi K","Sato R","Fukayama M","Isagawa T","Aburatani H","Yamamoto S","Komura D","Tanaka M","Katoh H","Tatsuno K"],"additional_accession":[]},"is_claimable":false,"name":"CASTIN: a system for comprehensive analysis of cancer-stromal interactome.","description":"<h4>Background</h4>Cancer microenvironment plays a vital role in cancer development and progression, and cancer-stromal interactions have been recognized as important targets for cancer therapy. However, identifying relevant and druggable cancer-stromal interactions is challenging due to the lack of quantitative methods to analyze whole cancer-stromal interactome.<h4>Results</h4>We present CASTIN (CAncer-STromal INteractome analysis), a novel framework for the evaluation of cancer-stromal interactome from RNA-Seq data using cancer xenograft models. For each ligand-receptor interaction which is derived from curated protein-protein interaction database, CASTIN summarizes gene expression profiles of cancer and stroma into three evaluation indices. These indices provide quantitative evaluation","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Nov","modification":"2026-06-07T07:51:44.977Z","creation":"2025-05-29T20:21:40.68Z"},"accession":"S-EPMC5103609","cross_references":{"pubmed":["27829362"],"doi":["10.1186/s12864-016-3207-z"]}}