biostudies-literatureUnknown53(10)Glombik KKNOW, sponsored by the Ministry of Science and Higher Education, PolandStatutory Funds of the Department of Experimental Neuroendocrinology Institute of Pharmacology Polish Academy of SciencesA growing body of evidence has focused on the impact of mitochondrial disturbances in the development of depression, but little data exist regarding the effects of chronic administration of antidepressant drugs on the brain's mitochondrial protein profile. The aim of this study was to investigate the impact of chronic treatment with an atypical antidepressant drug-tianeptine-on the mitochondria-enriched subproteome profile in the hippocampus and the frontal cortex of 3-month-old male rats following a prenatal stress procedure. Rats that were exposed to a prenatal stress procedure displayed depressive- and anxiety-like disturbances based on the elevated plus-maze and Porsolt tests. Moreover, two-dimensional electrophoresis coupled with mass spectrometry showed structure-dependent mitoproteoMolecular neurobiology7351-7362https://www.ebi.ac.uk/biostudies/studies/S-EPMC5104776biostudies-literatureThe effect of chronic tianeptine administration on the brain mitochondria: direct links with an animal model of depression.PMC5104776Slusarczyk JSpedding MBasta-Kaim AOlszanecki RKubera MBudziszewska BLason WStachowicz ATrojan EGlombik KfalseThe effect of chronic tianeptine administration on the brain mitochondria: direct links with an animal model of depression.A growing body of evidence has focused on the impact of mitochondrial disturbances in the development of depression, but little data exist regarding the effects of chronic administration of antidepressant drugs on the brain's mitochondrial protein profile. The aim of this study was to investigate the impact of chronic treatment with an atypical antidepressant drug-tianeptine-on the mitochondria-enriched subproteome profile in the hippocampus and the frontal cortex of 3-month-old male rats following a prenatal stress procedure. Rats that were exposed to a prenatal stress procedure displayed depressive- and anxiety-like disturbances based on the elevated plus-maze and Porsolt tests. Moreover, two-dimensional electrophoresis coupled with mass spectrometry showed structure-dependent mitoproteo2016-01-01T00:00:00Z2016 Dec2025-04-04T14:58:19.524Z2019-03-27T02:28:46ZS-EPMC51047762693488810.1007/s12035-016-9807-4