{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tan KP"],"funding":["NIEHS NIH HHS"],"pagination":["e2347"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5108328"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(8)"],"pubmed_abstract":["Alpha1,2-fucosyltransferases, FUT1 and FUT2, which transfer fucoses onto the terminal galactose of N-acetyl-lactosamine via α1,2-linkage have been shown to be highly expressed in various types of cancers. A few studies have shown the involvement of FUT1 substrates in tumor cell proliferation and migration. Lysosome-associated membrane protein 1, LAMP-1, has been reported to carry alpha1,2-fucosylated Lewis Y (LeY) antigens in breast cancer cells, however, the biological functions of LeY on LAMP-1 remain largely unknown. Whether or not its family member, LAMP-2, displays similar modifications and functions as LAMP-1 has not yet been addressed. In this study, we have presented evidence supporting that both LAMP-1 and 2 are substrates for FUT1, but not FUT2. We have also demonstrated the pres"],"journal":["Cell death & disease"],"pubmed_title":["Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells."],"pmcid":["PMC5108328"],"funding_grant_id":["27307C0012"],"pubmed_authors":["Cho HC","Hung JT","Tan KP","Yu AL","Ho MY","Yu J"],"additional_accession":[]},"is_claimable":false,"name":"Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells.","description":"Alpha1,2-fucosyltransferases, FUT1 and FUT2, which transfer fucoses onto the terminal galactose of N-acetyl-lactosamine via α1,2-linkage have been shown to be highly expressed in various types of cancers. A few studies have shown the involvement of FUT1 substrates in tumor cell proliferation and migration. Lysosome-associated membrane protein 1, LAMP-1, has been reported to carry alpha1,2-fucosylated Lewis Y (LeY) antigens in breast cancer cells, however, the biological functions of LeY on LAMP-1 remain largely unknown. Whether or not its family member, LAMP-2, displays similar modifications and functions as LAMP-1 has not yet been addressed. In this study, we have presented evidence supporting that both LAMP-1 and 2 are substrates for FUT1, but not FUT2. We have also demonstrated the pres","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Aug","modification":"2025-04-04T11:18:26.878Z","creation":"2019-03-27T02:28:55Z"},"accession":"S-EPMC5108328","cross_references":{"pubmed":["27560716"],"doi":["10.1038/cddis.2016.243"]}}