{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["55(38)"],"submitter":["Thomas A"],"pubmed_abstract":["The ground-state deprotection of a simple alkynylsilane is studied under vibrational strong coupling to the zero-point fluctuations, or vacuum electromagnetic field, of a resonant IR microfluidic cavity. The reaction rate decreased by a factor of up to 5.5 when the Si-C vibrational stretching modes of the reactant were strongly coupled. The relative change in the reaction rate under strong coupling depends on the Rabi splitting energy. Product analysis by GC-MS confirmed the kinetic results. Temperature dependence shows that the activation enthalpy and entropy change significantly, suggesting that the transition state is modified from an associative to a dissociative type. These findings show that vibrational strong coupling provides a powerful approach for modifying and controlling chemical landscapes and for understanding reaction mechanisms."],"journal":["Angewandte Chemie (International ed. in English)"],"pagination":["11462-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5113700"],"repository":["biostudies-literature"],"pubmed_title":["Ground-State Chemical Reactivity under Vibrational Coupling to the Vacuum Electromagnetic Field."],"pmcid":["PMC5113700"],"pubmed_authors":["George J","Ebbesen TW","Genet C","Dryzhakov M","Thomas A","Chervy T","Varma SJ","Moran J","Zhong X","Devaux E","Shalabney A","Hutchison JA"],"additional_accession":[]},"is_claimable":false,"name":"Ground-State Chemical Reactivity under Vibrational Coupling to the Vacuum Electromagnetic Field.","description":"The ground-state deprotection of a simple alkynylsilane is studied under vibrational strong coupling to the zero-point fluctuations, or vacuum electromagnetic field, of a resonant IR microfluidic cavity. The reaction rate decreased by a factor of up to 5.5 when the Si-C vibrational stretching modes of the reactant were strongly coupled. The relative change in the reaction rate under strong coupling depends on the Rabi splitting energy. Product analysis by GC-MS confirmed the kinetic results. Temperature dependence shows that the activation enthalpy and entropy change significantly, suggesting that the transition state is modified from an associative to a dissociative type. These findings show that vibrational strong coupling provides a powerful approach for modifying and controlling chemical landscapes and for understanding reaction mechanisms.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Sep","modification":"2025-04-04T10:06:02.76Z","creation":"2019-03-27T02:29:12Z"},"accession":"S-EPMC5113700","cross_references":{"pubmed":["27529831"],"doi":["10.1002/anie.201605504"]}}