{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Little AC"],"funding":["NHLBI NIH HHS"],"pagination":["e261"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5117847"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(10)"],"pubmed_abstract":["Dual oxidase 1 (DUOX1) is an oxidant-generating enzyme within the airway epithelium that participates in innate airway host defense and epithelial homeostasis. Recent studies indicate that DUOX1 is suppressed in lung cancers by epigenetic silencing, although the importance of DUOX1 silencing in lung cancer development or progression is unknown. Here we show that loss of DUOX1 expression in a panel of lung cancer cell lines is strongly associated with loss of the epithelial marker E-cadherin. Moreover, RNAi-mediated DUOX1 silencing in lung epithelial cells and the cancer cell line NCI-H292 was found to result in loss of epithelial characteristics/molecular features (altered morphology, reduced barrier function and loss of E-cadherin) and increased mesenchymal features (increased migration, "],"journal":["Oncogenesis"],"pubmed_title":["DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties."],"pmcid":["PMC5117847"],"funding_grant_id":["T32 HL076122","R01 HL085646","F32 HL129706"],"pubmed_authors":["van der Vliet A","Habibovic A","Danyal K","Bauer RA","Hristova M","Sham D","Little AC","Sipsey LM","Heppner DE"],"additional_accession":[]},"is_claimable":false,"name":"DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties.","description":"Dual oxidase 1 (DUOX1) is an oxidant-generating enzyme within the airway epithelium that participates in innate airway host defense and epithelial homeostasis. Recent studies indicate that DUOX1 is suppressed in lung cancers by epigenetic silencing, although the importance of DUOX1 silencing in lung cancer development or progression is unknown. Here we show that loss of DUOX1 expression in a panel of lung cancer cell lines is strongly associated with loss of the epithelial marker E-cadherin. Moreover, RNAi-mediated DUOX1 silencing in lung epithelial cells and the cancer cell line NCI-H292 was found to result in loss of epithelial characteristics/molecular features (altered morphology, reduced barrier function and loss of E-cadherin) and increased mesenchymal features (increased migration, ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Oct","modification":"2026-03-16T15:34:06.075Z","creation":"2019-03-27T02:29:27Z"},"accession":"S-EPMC5117847","cross_references":{"pubmed":["27694834"],"doi":["10.1038/oncsis.2016.61"]}}