{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(11)"],"submitter":["Tanabe S"],"pubmed_abstract":["<h4>Aim</h4>To investigate β-catenin (CTNNB1) signaling in cancer and stem cells, the gene expression and pathway were analyzed using bioinformatics.<h4>Methods</h4>The expression of the catenin β 1 (<i>CTNNB1</i>) gene, which codes for β-catenin, was analyzed in mesenchymal stem cells (MSCs) and gastric cancer (GC) cells. Beta-catenin signaling and the mutation of related proteins were also analyzed using the cBioPortal for Cancer Genomics and HOMology modeling of Complex Structure (HOMCOS) databases.<h4>Results</h4>The expression of the <i>CTNNB1</i> gene was up-regulated in GC cells compared to MSCs. The expression of EPH receptor A8 (EPHA8), synovial sarcoma translocation chromosome 18 (SS18), interactor of little elongation complex ELL subunit 1 (ICE1), patched 1 (PTCH1), mutS homolog"],"journal":["World journal of stem cells"],"pagination":["384-395"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5120243"],"repository":["biostudies-literature"],"pubmed_title":["Gene expression and pathway analysis of <i>CTNNB1</i> in cancer and stem cells."],"pmcid":["PMC5120243"],"pubmed_authors":["Kawabata T","Aoyagi K","Sasaki H","Yokozaki H","Tanabe S"],"additional_accession":[]},"is_claimable":false,"name":"Gene expression and pathway analysis of <i>CTNNB1</i> in cancer and stem cells.","description":"<h4>Aim</h4>To investigate β-catenin (CTNNB1) signaling in cancer and stem cells, the gene expression and pathway were analyzed using bioinformatics.<h4>Methods</h4>The expression of the catenin β 1 (<i>CTNNB1</i>) gene, which codes for β-catenin, was analyzed in mesenchymal stem cells (MSCs) and gastric cancer (GC) cells. Beta-catenin signaling and the mutation of related proteins were also analyzed using the cBioPortal for Cancer Genomics and HOMology modeling of Complex Structure (HOMCOS) databases.<h4>Results</h4>The expression of the <i>CTNNB1</i> gene was up-regulated in GC cells compared to MSCs. The expression of EPH receptor A8 (EPHA8), synovial sarcoma translocation chromosome 18 (SS18), interactor of little elongation complex ELL subunit 1 (ICE1), patched 1 (PTCH1), mutS homolog","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Nov","modification":"2025-04-22T21:18:05.476Z","creation":"2019-03-27T02:29:36Z"},"accession":"S-EPMC5120243","cross_references":{"pubmed":["27928465"],"doi":["10.4252/wjsc.v8.i11.384"]}}