biostudies-literatureUnknown8(11)Tanabe S<h4>Aim</h4>To investigate β-catenin (CTNNB1) signaling in cancer and stem cells, the gene expression and pathway were analyzed using bioinformatics.<h4>Methods</h4>The expression of the catenin β 1 (<i>CTNNB1</i>) gene, which codes for β-catenin, was analyzed in mesenchymal stem cells (MSCs) and gastric cancer (GC) cells. Beta-catenin signaling and the mutation of related proteins were also analyzed using the cBioPortal for Cancer Genomics and HOMology modeling of Complex Structure (HOMCOS) databases.<h4>Results</h4>The expression of the <i>CTNNB1</i> gene was up-regulated in GC cells compared to MSCs. The expression of EPH receptor A8 (EPHA8), synovial sarcoma translocation chromosome 18 (SS18), interactor of little elongation complex ELL subunit 1 (ICE1), patched 1 (PTCH1), mutS homologWorld journal of stem cells384-395https://www.ebi.ac.uk/biostudies/studies/S-EPMC5120243biostudies-literatureGene expression and pathway analysis of <i>CTNNB1</i> in cancer and stem cells.PMC5120243Kawabata TAoyagi KSasaki HYokozaki HTanabe SfalseGene expression and pathway analysis of <i>CTNNB1</i> in cancer and stem cells.<h4>Aim</h4>To investigate β-catenin (CTNNB1) signaling in cancer and stem cells, the gene expression and pathway were analyzed using bioinformatics.<h4>Methods</h4>The expression of the catenin β 1 (<i>CTNNB1</i>) gene, which codes for β-catenin, was analyzed in mesenchymal stem cells (MSCs) and gastric cancer (GC) cells. Beta-catenin signaling and the mutation of related proteins were also analyzed using the cBioPortal for Cancer Genomics and HOMology modeling of Complex Structure (HOMCOS) databases.<h4>Results</h4>The expression of the <i>CTNNB1</i> gene was up-regulated in GC cells compared to MSCs. The expression of EPH receptor A8 (EPHA8), synovial sarcoma translocation chromosome 18 (SS18), interactor of little elongation complex ELL subunit 1 (ICE1), patched 1 (PTCH1), mutS homolog2016-01-01T00:00:00Z2016 Nov2025-04-22T21:18:05.476Z2019-03-27T02:29:36ZS-EPMC51202432792846510.4252/wjsc.v8.i11.384