{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Burke TM"],"funding":["NCATS NIH HHS","NCRR NIH HHS","NIDDK NIH HHS","NHLBI NIH HHS","NINDS NIH HHS"],"pagination":["364-371"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5124508"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(4)"],"pubmed_abstract":["Sleep inertia, sleep homeostatic and circadian processes modulate cognition, including reaction time, memory, mood and alertness. How these processes influence higher-order cognitive functions is not well known. Six participants completed a 73-day-long study that included two 14-day-long 28-h forced desynchrony protocols to examine separate and interacting influences of sleep inertia, sleep homeostasis and circadian phase on higher-order cognitive functions of inhibitory control and selective visual attention. Cognitive performance for most measures was impaired immediately after scheduled awakening and improved during the first ~2-4 h of wakefulness (decreasing sleep inertia); worsened thereafter until scheduled bedtime (increasing sleep homeostasis); and was worst at ~60° and best at ~240° (circadian modulation, with worst and best phases corresponding to ~09:00 and ~21:00 hours, respectively, in individuals with a habitual wake time of 07:00 hours). The relative influences of sleep inertia, sleep homeostasis and circadian phase depended on the specific higher-order cognitive function task examined. Inhibitory control appeared to be modulated most strongly by circadian phase, whereas selective visual attention for a spatial-configuration search task was modulated most strongly by sleep inertia. These findings demonstrate that some higher-order cognitive processes are differentially sensitive to different sleep-wake regulatory processes. Differential modulation of cognitive functions by different sleep-wake regulatory processes has important implications for understanding mechanisms contributing to performance impairments during adverse circadian phases, sleep deprivation and/or upon awakening from sleep."],"journal":["Journal of sleep research"],"pubmed_title":["Sleep inertia, sleep homeostatic and circadian influences on higher-order cognitive functions."],"pmcid":["PMC5124508"],"funding_grant_id":["1UL1 TR001102","P30-HL101299","UL1 TR001102","R01-HL081761","M01 RR002635","R01 HL085705","R01-NS41886","R01-HL085705","P30 DK048520","R01 HL081761","M01-RR02635","R01 HL094806","R01 NS041886","P30 HL101299","R01 HL109706"],"pubmed_authors":["Burke TM","Scheer FAJL","Ronda JM","Wright KP","Czeisler CA"],"additional_accession":[]},"is_claimable":false,"name":"Sleep inertia, sleep homeostatic and circadian influences on higher-order cognitive functions.","description":"Sleep inertia, sleep homeostatic and circadian processes modulate cognition, including reaction time, memory, mood and alertness. How these processes influence higher-order cognitive functions is not well known. Six participants completed a 73-day-long study that included two 14-day-long 28-h forced desynchrony protocols to examine separate and interacting influences of sleep inertia, sleep homeostasis and circadian phase on higher-order cognitive functions of inhibitory control and selective visual attention. Cognitive performance for most measures was impaired immediately after scheduled awakening and improved during the first ~2-4 h of wakefulness (decreasing sleep inertia); worsened thereafter until scheduled bedtime (increasing sleep homeostasis); and was worst at ~60° and best at ~240° (circadian modulation, with worst and best phases corresponding to ~09:00 and ~21:00 hours, respectively, in individuals with a habitual wake time of 07:00 hours). The relative influences of sleep inertia, sleep homeostasis and circadian phase depended on the specific higher-order cognitive function task examined. Inhibitory control appeared to be modulated most strongly by circadian phase, whereas selective visual attention for a spatial-configuration search task was modulated most strongly by sleep inertia. These findings demonstrate that some higher-order cognitive processes are differentially sensitive to different sleep-wake regulatory processes. Differential modulation of cognitive functions by different sleep-wake regulatory processes has important implications for understanding mechanisms contributing to performance impairments during adverse circadian phases, sleep deprivation and/or upon awakening from sleep.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Aug","modification":"2020-10-29T13:34:08Z","creation":"2019-03-27T02:29:54Z"},"accession":"S-EPMC5124508","cross_references":{"pubmed":["25773686"],"doi":["10.1111/jsr.12291"]}}