biostudies-literatureLandis BJNICHD NIH HHS30-52https://www.ebi.ac.uk/biostudies/studies/S-EPMC5125077biostudies-literatureUnknown26(1)CHD is frequently associated with a genetic syndrome. These syndromes often present specific cardiovascular and non-cardiovascular co-morbidities that confer significant peri-operative risks affecting multiple organ systems. Although surgical outcomes have improved over time, these co-morbidities continue to contribute substantially to poor peri-operative mortality and morbidity outcomes. Peri-operative morbidity may have long-standing ramifications on neurodevelopment and overall health. Recognising the cardiovascular and non-cardiovascular risks associated with specific syndromic diagnoses will facilitate expectant management, early detection of clinical problems, and improved outcomes--for example, the development of syndrome-based protocols for peri-operative evaluation and prophylactic actions may improve outcomes for the more frequently encountered syndromes such as 22q11 deletion syndrome.Cardiology in the youngCHD associated with syndromic diagnoses: peri-operative risk factors and early outcomes.PMC5125077K12 HD068371Landis BJHinton RBCooper DSfalseCHD associated with syndromic diagnoses: peri-operative risk factors and early outcomes.CHD is frequently associated with a genetic syndrome. These syndromes often present specific cardiovascular and non-cardiovascular co-morbidities that confer significant peri-operative risks affecting multiple organ systems. Although surgical outcomes have improved over time, these co-morbidities continue to contribute substantially to poor peri-operative mortality and morbidity outcomes. Peri-operative morbidity may have long-standing ramifications on neurodevelopment and overall health. Recognising the cardiovascular and non-cardiovascular risks associated with specific syndromic diagnoses will facilitate expectant management, early detection of clinical problems, and improved outcomes--for example, the development of syndrome-based protocols for peri-operative evaluation and prophylactic actions may improve outcomes for the more frequently encountered syndromes such as 22q11 deletion syndrome.2016-01-01T00:00:00Z2016 Jan2024-11-13T00:03:39.462Z2019-03-27T02:29:57ZS-EPMC51250772634537410.1017/s104795111500138910.1017/S1047951115001389