biostudies-literatureUnknown7Maruyama FNucleocytoplasmic DNA viruses are a large group of viruses that harbor double-stranded DNA genomes with sizes of several 100 kbp, challenging the traditional concept of viruses as small, simple 'organisms at the edge of life.' The most intriguing questions about them may be their origin and evolution, which have yielded the variety we see today. Specifically, the phyletic relationship between two giant dsDNA virus families that are presumed to be close, <i>Mimiviridae</i>, which infect <i>Acanthamoeba</i>, and <i>Phycodnaviridae</i>, which infect algae, is still obscure and needs to be clarified by in-depth analysis. Here, we studied <i>Mimiviridae</i>-<i>Phycodnaviridae</i> phylogeny including the newly identified <i>Heterosigma akashiwo virus</i> strain <i>HaV53</i>. Gene-to-gene compariFrontiers in microbiology1942https://www.ebi.ac.uk/biostudies/studies/S-EPMC5127864biostudies-literatureEvolution and Phylogeny of Large DNA Viruses, <i>Mimiviridae</i> and <i>Phycodnaviridae</i> Including Newly Characterized <i>Heterosigma akashiwo Viru</i>s.PMC5127864Maruyama FUeki SfalseEvolution and Phylogeny of Large DNA Viruses, <i>Mimiviridae</i> and <i>Phycodnaviridae</i> Including Newly Characterized <i>Heterosigma akashiwo Viru</i>s.Nucleocytoplasmic DNA viruses are a large group of viruses that harbor double-stranded DNA genomes with sizes of several 100 kbp, challenging the traditional concept of viruses as small, simple 'organisms at the edge of life.' The most intriguing questions about them may be their origin and evolution, which have yielded the variety we see today. Specifically, the phyletic relationship between two giant dsDNA virus families that are presumed to be close, <i>Mimiviridae</i>, which infect <i>Acanthamoeba</i>, and <i>Phycodnaviridae</i>, which infect algae, is still obscure and needs to be clarified by in-depth analysis. Here, we studied <i>Mimiviridae</i>-<i>Phycodnaviridae</i> phylogeny including the newly identified <i>Heterosigma akashiwo virus</i> strain <i>HaV53</i>. Gene-to-gene compari2016-01-01T00:00:00Z20162026-04-07T17:54:03.268Z2019-03-27T02:30:11ZS-EPMC51278642796565910.3389/fmicb.2016.01942