{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["41(2)"],"submitter":["Cristino L"],"pubmed_abstract":["Pain perception can become altered in individuals with eating disorders and obesity for reasons that have not been fully elucidated. We show that leptin deficiency in ob/ob mice, or leptin insensitivity in the arcuate nucleus of the hypothalamus in mice with high-fat diet (HFD)-induced obesity, are accompanied by elevated orexin-A (OX-A) levels and orexin receptor-1 (OX1-R)-dependent elevation of the levels of the endocannabinoid, 2-arachidonoylglycerol (2-AG), in the ventrolateral periaqueductal gray (vlPAG). In ob/ob mice, these alterations result in the following: (i) increased excitability of OX1-R-expressing vlPAG output neurons and subsequent increased OFF and decreased ON cell activity in the rostral ventromedial medulla, as assessed by patch clamp and in vivo electrophysiology; and"],"journal":["Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"],"pagination":["508-20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5130126"],"repository":["biostudies-literature"],"pubmed_title":["Orexin-A and Endocannabinoid Activation of the Descending Antinociceptive Pathway Underlies Altered Pain Perception in Leptin Signaling Deficiency."],"pmcid":["PMC5130126"],"pubmed_authors":["Di Marzo V","Luongo L","Imperatore R","Maione S","Boccella S","Becker T","Cristino L","Piscitelli F","Busetto G","Morello G"],"additional_accession":[]},"is_claimable":false,"name":"Orexin-A and Endocannabinoid Activation of the Descending Antinociceptive Pathway Underlies Altered Pain Perception in Leptin Signaling Deficiency.","description":"Pain perception can become altered in individuals with eating disorders and obesity for reasons that have not been fully elucidated. We show that leptin deficiency in ob/ob mice, or leptin insensitivity in the arcuate nucleus of the hypothalamus in mice with high-fat diet (HFD)-induced obesity, are accompanied by elevated orexin-A (OX-A) levels and orexin receptor-1 (OX1-R)-dependent elevation of the levels of the endocannabinoid, 2-arachidonoylglycerol (2-AG), in the ventrolateral periaqueductal gray (vlPAG). In ob/ob mice, these alterations result in the following: (i) increased excitability of OX1-R-expressing vlPAG output neurons and subsequent increased OFF and decreased ON cell activity in the rostral ventromedial medulla, as assessed by patch clamp and in vivo electrophysiology; and","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2025-05-29T19:22:00.033Z","creation":"2025-05-29T19:22:00.033Z"},"accession":"S-EPMC5130126","cross_references":{"pubmed":["26081302"],"doi":["10.1038/npp.2015.173"]}}