{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rebollo-Mesa I"],"funding":["Comisión Nacional de Investigación Científica y Tecnológica","Guy's and St Thomas' Charity","Medical Research Council","National Institute for Health Research (NIHR)","Seventh Framework Programme","King’s College London","Guy's and St Thomas' NHS Foundation Trust"],"pagination":["3443-3457"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5132071"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(12)"],"pubmed_abstract":["We and others have previously described signatures of tolerance in kidney transplantation showing the differential expression of B cell-related genes and the relative expansions of B cell subsets. However, in all of these studies, the index group-namely, the tolerant recipients-were not receiving immunosuppression (IS) treatment, unlike the rest of the comparator groups. We aimed to assess the confounding effect of these regimens and develop a novel IS-independent signature of tolerance. Analyzing gene expression in three independent kidney transplant patient cohorts (232 recipients and 14 tolerant patients), we have established that the expression of the previously reported signature was biased by IS regimens, which also influenced transitional B cells. We have defined and validated a new"],"journal":["American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"],"pubmed_title":["Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?"],"pmcid":["PMC5132071"],"funding_grant_id":["G0801537","FP7/2007-2013","G0801537/ID: 88245","305147","HEALTH-F5-2010-260687","R090782","MR/J006742/1","R080530"],"pubmed_authors":["Indices of Tolerance EU Consortium","Game D","Tucker B","Macphee I","Pararajasingam R","Carr S","Norris S","McKane W","Bhandari S","Kon SP","Mobillo P","Griffin S","Mohaupt MG","Hilton R","Christakoudi S","Smallcombe N","Lechler RI","Viklicky O","Lord GM","Marks S","Rebollo-Mesa I","Lewis R","Sinha MD","Kamra Y","Hernandez-Fuentes MP","Nova-Lamperti E","Mark PB","Seron D","Runglall M","Berglund D","Baker R","Kalra PA"],"additional_accession":[]},"is_claimable":false,"name":"Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?","description":"We and others have previously described signatures of tolerance in kidney transplantation showing the differential expression of B cell-related genes and the relative expansions of B cell subsets. However, in all of these studies, the index group-namely, the tolerant recipients-were not receiving immunosuppression (IS) treatment, unlike the rest of the comparator groups. We aimed to assess the confounding effect of these regimens and develop a novel IS-independent signature of tolerance. Analyzing gene expression in three independent kidney transplant patient cohorts (232 recipients and 14 tolerant patients), we have established that the expression of the previously reported signature was biased by IS regimens, which also influenced transitional B cells. We have defined and validated a new","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Dec","modification":"2026-05-04T23:09:43.969Z","creation":"2025-06-01T03:27:48.421Z"},"accession":"S-EPMC5132071","cross_references":{"pubmed":["27328267"],"doi":["10.1111/ajt.13932"]}}