{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(10)"],"submitter":["Li L"],"pubmed_abstract":["Understanding the mechanisms that lead to autoimmunity is critical for defining potential therapeutic pathways. In this regard there have been considerable efforts in investigating the interacting roles of TGF-β and IL-2 on the function regulatory T cells. We have taken advantage of dnTGF-βRII Il2ra<sup>-/-</sup> (abbreviated as Il2ra<sup>-/-</sup>Tg) mouse model, which allows a direct mechanistic approach to define the relative roles of TGF-β and IL-2 on Treg development. Il2ra<sup>-/-</sup>Tg mice spontaneously developed multi-organ autoimmune diseases with expansion of pathogenic T cells and enhanced germinal center response at 3-4 weeks of age. Importantly, peripheral Treg cells from Il2ra<sup>-/-</sup>Tg mice demonstrated an activated Th1-like stable phenotype and normal in vitro supp"],"journal":["Cell death & disease"],"pagination":["e2439"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5134002"],"repository":["biostudies-literature"],"pubmed_title":["Block of both TGF-β and IL-2 signaling impedes Neurophilin-1<sup>+</sup> regulatory T cell and follicular regulatory T cell development."],"pmcid":["PMC5134002"],"pubmed_authors":["Ma HD","Yao Y","Xie YQ","Gershwin M","Yang YQ","Yang SH","Yin XY","Lian ZX","Li L","Wang YH"],"additional_accession":[]},"is_claimable":false,"name":"Block of both TGF-β and IL-2 signaling impedes Neurophilin-1<sup>+</sup> regulatory T cell and follicular regulatory T cell development.","description":"Understanding the mechanisms that lead to autoimmunity is critical for defining potential therapeutic pathways. In this regard there have been considerable efforts in investigating the interacting roles of TGF-β and IL-2 on the function regulatory T cells. We have taken advantage of dnTGF-βRII Il2ra<sup>-/-</sup> (abbreviated as Il2ra<sup>-/-</sup>Tg) mouse model, which allows a direct mechanistic approach to define the relative roles of TGF-β and IL-2 on Treg development. Il2ra<sup>-/-</sup>Tg mice spontaneously developed multi-organ autoimmune diseases with expansion of pathogenic T cells and enhanced germinal center response at 3-4 weeks of age. Importantly, peripheral Treg cells from Il2ra<sup>-/-</sup>Tg mice demonstrated an activated Th1-like stable phenotype and normal in vitro supp","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Oct","modification":"2025-04-03T23:23:38.561Z","creation":"2019-03-27T02:30:34Z"},"accession":"S-EPMC5134002","cross_references":{"pubmed":["27787514"],"doi":["10.1038/cddis.2016.348"]}}