biostudies-literatureUnknown7(Suppl 35)Lemaire JJ<h4>Background</h4>Deep brain stimulation (DBS) in Parkinson's disease uses bi-hemispheric high-frequency stimulation within the subthalamus, however, the specific impacts of bilaterality of DBS are still not clear. Thus, we aimed to study the individual-level clinical impact of locations of right-left contact pair-up accounting for each subthalamic nucleus (STN) anatomy.<h4>Methods</h4>Contact locations and effects at 1 year were studied retrospectively in an unselected series of 53 patients operated between 2004 and 2010. Location of contacts was defined relatively to the main axis of STN used to map longitudinal and transversal positions, and STN membership (out meaning out-of-STN). Contact pairings were described via three methods: (i) Unified contact location (UCL) collapsing DBS intoSurgical neurology internationalS837-S847https://www.ebi.ac.uk/biostudies/studies/S-EPMC5134117biostudies-literatureSubthalamus stimulation in Parkinson disease: Accounting for the bilaterality of contacts.PMC5134117Derost PColl GMarques ADurif FPereira BCoste JUlla MLemaire JJMorand DDebilly BVassal FGabrillargues JfalseSubthalamus stimulation in Parkinson disease: Accounting for the bilaterality of contacts.<h4>Background</h4>Deep brain stimulation (DBS) in Parkinson's disease uses bi-hemispheric high-frequency stimulation within the subthalamus, however, the specific impacts of bilaterality of DBS are still not clear. Thus, we aimed to study the individual-level clinical impact of locations of right-left contact pair-up accounting for each subthalamic nucleus (STN) anatomy.<h4>Methods</h4>Contact locations and effects at 1 year were studied retrospectively in an unselected series of 53 patients operated between 2004 and 2010. Location of contacts was defined relatively to the main axis of STN used to map longitudinal and transversal positions, and STN membership (out meaning out-of-STN). Contact pairings were described via three methods: (i) Unified contact location (UCL) collapsing DBS into2016-01-01T00:00:00Z20162025-06-01T01:10:24.598Z2025-06-01T01:10:24.598ZS-EPMC51341172799031610.4103/2152-7806.194066