{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(11)"],"submitter":["Xu Z"],"pubmed_abstract":["Variation in genes implicated in monoamine neurotransmission may interact with environmental factors to influence antidepressant response. We aimed to determine how a range of single nucleotide polymorphisms in monoaminergic genes influence this response to treatment and how they interact with childhood trauma and recent life stress in a Chinese sample. An initial study of monoaminergic coding region single nucleotide polymorphisms identified significant associations of TPH2 and HTR1B single nucleotide polymorphisms with treatment response that showed interactions with childhood and recent life stress, respectively (Xu et al., 2012). A total of 47 further single nucleotide polymorphisms in 17 candidate monoaminergic genes were genotyped in 281 Chinese Han patients with major depressive dis"],"journal":["The international journal of neuropsychopharmacology"],"pagination":["pyw070"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5137282"],"repository":["biostudies-literature"],"pubmed_title":["TPH-2 Polymorphisms Interact with Early Life Stress to Influence Response to Treatment with Antidepressant Drugs."],"pmcid":["PMC5137282"],"pubmed_authors":["Pu M","Zhang Z","Reynolds GP","Xu Z","Yuan Y","Shi Y"],"additional_accession":[]},"is_claimable":false,"name":"TPH-2 Polymorphisms Interact with Early Life Stress to Influence Response to Treatment with Antidepressant Drugs.","description":"Variation in genes implicated in monoamine neurotransmission may interact with environmental factors to influence antidepressant response. We aimed to determine how a range of single nucleotide polymorphisms in monoaminergic genes influence this response to treatment and how they interact with childhood trauma and recent life stress in a Chinese sample. An initial study of monoaminergic coding region single nucleotide polymorphisms identified significant associations of TPH2 and HTR1B single nucleotide polymorphisms with treatment response that showed interactions with childhood and recent life stress, respectively (Xu et al., 2012). A total of 47 further single nucleotide polymorphisms in 17 candidate monoaminergic genes were genotyped in 281 Chinese Han patients with major depressive dis","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Nov","modification":"2025-06-01T00:10:15.683Z","creation":"2025-06-01T00:10:15.683Z"},"accession":"S-EPMC5137282","cross_references":{"pubmed":["27521242"],"doi":["10.1093/ijnp/pyw070"]}}