{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cibrian D"],"funding":["European Research Council"],"pagination":["985-96"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5146640"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(8)"],"pubmed_abstract":["The activation marker CD69 is expressed by skin γδ T cells. Here we found that CD69 controlled the aryl hydrocarbon receptor (AhR)-dependent secretion of interleukin 22 (IL-22) by γδ T cells, which contributed to the development of psoriasis induced by IL-23. CD69 associated with the aromatic-amino-acid-transporter complex LAT1-CD98 and regulated its surface expression and uptake of L-tryptophan (L-Trp) and the intracellular quantity of L-Trp-derived activators of AhR. In vivo administration of L-Trp, an inhibitor of AhR or IL-22 abrogated the differences between CD69-deficient mice and wild-type mice in skin inflammation. We also observed LAT1-mediated regulation of AhR activation and IL-22 secretion in circulating Vγ9(+) γδ T cells of psoriatic patients. Thus, CD69 serves as a key mediat"],"journal":["Nature immunology"],"pubmed_title":["CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis."],"pmcid":["PMC5146640"],"funding_grant_id":["294340"],"pubmed_authors":["Cibrian D","Punzon C","Vazquez J","Saiz ML","Moreno-Gonzalo O","Fernandez-Salguero PM","Sanchez-Madrid F","de la Fuente H","Fresno M","Vicente-Manzanares M","Sanchez-Diaz R","Ferrarini A","Martin P","Jorge I","Dauden E"],"additional_accession":[]},"is_claimable":false,"name":"CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis.","description":"The activation marker CD69 is expressed by skin γδ T cells. Here we found that CD69 controlled the aryl hydrocarbon receptor (AhR)-dependent secretion of interleukin 22 (IL-22) by γδ T cells, which contributed to the development of psoriasis induced by IL-23. CD69 associated with the aromatic-amino-acid-transporter complex LAT1-CD98 and regulated its surface expression and uptake of L-tryptophan (L-Trp) and the intracellular quantity of L-Trp-derived activators of AhR. In vivo administration of L-Trp, an inhibitor of AhR or IL-22 abrogated the differences between CD69-deficient mice and wild-type mice in skin inflammation. We also observed LAT1-mediated regulation of AhR activation and IL-22 secretion in circulating Vγ9(+) γδ T cells of psoriatic patients. Thus, CD69 serves as a key mediat","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Aug","modification":"2025-04-18T18:25:51.382Z","creation":"2019-03-27T02:31:11Z"},"accession":"S-EPMC5146640","cross_references":{"pubmed":["27376471"],"doi":["10.1038/ni.3504"]}}