{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(3)"],"submitter":["Ghanei S"],"pubmed_abstract":["In recent years, the chemistry of 2-chloroquinoline-3-carbaldehydes have received considerable attention owing to their synthetic and effective biological importance which exhibits a wide variety of biological activity, N<sup>1</sup>,N<sup>4</sup>-bis((2-chloroquinolin-3-yl)methylene)benzene-1,4-diamine derivatives that synthesized from 2-chloroquinoline-3-carbaldehydes may have biological effects. As the inhibitor of AKT1 (RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1), the aforementioned compounds may have implication in preventing complications of cancers. A group of N<sup>1</sup>, N<sup>4</sup>-bis ((2-chloroquinolin-3-yl) methylene) benzene-1, 4-diamine derivatives (3a-3i) (H, 6-Me, 6-OMe, 6-OEt, 6-Cl, 7-Me, 6-Et, 6-Isopropyl, 7-Cl) were "],"journal":["Iranian journal of pharmaceutical research : IJPR"],"pagination":["321-327"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5149018"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis and Docking Analysis of New Heterocyclic System N<sup>1</sup>, N<sup>4</sup>-bis (2-chloroquinolin-3-yl) methylene) benzene-1, 4-diamine as Potential Human AKT1 Inhibitor."],"pmcid":["PMC5149018"],"pubmed_authors":["Eshghi H","Ghanei S","Lari J","Saadatmandzadeh M"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis and Docking Analysis of New Heterocyclic System N<sup>1</sup>, N<sup>4</sup>-bis (2-chloroquinolin-3-yl) methylene) benzene-1, 4-diamine as Potential Human AKT1 Inhibitor.","description":"In recent years, the chemistry of 2-chloroquinoline-3-carbaldehydes have received considerable attention owing to their synthetic and effective biological importance which exhibits a wide variety of biological activity, N<sup>1</sup>,N<sup>4</sup>-bis((2-chloroquinolin-3-yl)methylene)benzene-1,4-diamine derivatives that synthesized from 2-chloroquinoline-3-carbaldehydes may have biological effects. As the inhibitor of AKT1 (RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1), the aforementioned compounds may have implication in preventing complications of cancers. A group of N<sup>1</sup>, N<sup>4</sup>-bis ((2-chloroquinolin-3-yl) methylene) benzene-1, 4-diamine derivatives (3a-3i) (H, 6-Me, 6-OMe, 6-OEt, 6-Cl, 7-Me, 6-Et, 6-Isopropyl, 7-Cl) were ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-06-01T00:57:11.372Z","creation":"2025-06-01T00:57:11.372Z"},"accession":"S-EPMC5149018","cross_references":{"pubmed":["27980566"]}}