{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Patel HH"],"funding":["National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["14226-14229"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5152571"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["138(43)"],"pubmed_abstract":["In this report, we describe the generation of remote allylic quaternary stereocenters β, γ, and δ relative to a carbonyl in high enantioselectivity. We utilize a redox-relay Heck reaction between alkenyl triflates and acyclic trisubstituted alkenols of varying chain-lengths. A wide array of terminal (E)-alkenyl triflates are suitable for this process. The utility of this functionalization is validated further by conversion of the products, via simple organic processes to access remotely functionalized chiral tertiary acid, amine, and alcohol products."],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Enantioselective Palladium-Catalyzed Alkenylation of Trisubstituted Alkenols To Form Allylic Quaternary Centers."],"pmcid":["PMC5152571"],"funding_grant_id":["R01 GM063540","NIGMS R01GM063540"],"pubmed_authors":["Patel HH","Sigman MS"],"additional_accession":[]},"is_claimable":false,"name":"Enantioselective Palladium-Catalyzed Alkenylation of Trisubstituted Alkenols To Form Allylic Quaternary Centers.","description":"In this report, we describe the generation of remote allylic quaternary stereocenters β, γ, and δ relative to a carbonyl in high enantioselectivity. We utilize a redox-relay Heck reaction between alkenyl triflates and acyclic trisubstituted alkenols of varying chain-lengths. A wide array of terminal (E)-alkenyl triflates are suitable for this process. The utility of this functionalization is validated further by conversion of the products, via simple organic processes to access remotely functionalized chiral tertiary acid, amine, and alcohol products.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Nov","modification":"2024-11-13T03:06:13.501Z","creation":"2019-03-27T02:31:17Z"},"accession":"S-EPMC5152571","cross_references":{"pubmed":["27768842"],"doi":["10.1021/jacs.6b09649"]}}