{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(1)"],"submitter":["Li Q"],"pubmed_abstract":["<h4>Objective</h4>Clinical response to the atypical antipsychotic paliperidone is known to vary among schizophrenic patients. We carried out a genome-wide association study to identify common genetic variants predictive of paliperidone efficacy.<h4>Methods</h4>We leveraged a collection of 1390 samples from individuals of European ancestry enrolled in 12 clinical studies investigating the efficacy of the extended-release tablet paliperidone ER (n1=490) and the once-monthly injection paliperidone palmitate (n2=550 and n3=350). We carried out a genome-wide association study using a general linear model (GLM) analysis on three separate cohorts, followed by meta-analysis and using a mixed linear model analysis on all samples. The variations in response explained by each single nucleotide polymo"],"journal":["Pharmacogenetics and genomics"],"pagination":["7-18"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5152628"],"repository":["biostudies-literature"],"pubmed_title":["Genome-wide association study of paliperidone efficacy."],"pmcid":["PMC5152628"],"pubmed_authors":["Savitz A","Schork NJ","Fu DJ","Alphs L","Cohen N","Libiger O","Li Q","Gopal S","Wineinger NE"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide association study of paliperidone efficacy.","description":"<h4>Objective</h4>Clinical response to the atypical antipsychotic paliperidone is known to vary among schizophrenic patients. We carried out a genome-wide association study to identify common genetic variants predictive of paliperidone efficacy.<h4>Methods</h4>We leveraged a collection of 1390 samples from individuals of European ancestry enrolled in 12 clinical studies investigating the efficacy of the extended-release tablet paliperidone ER (n1=490) and the once-monthly injection paliperidone palmitate (n2=550 and n3=350). We carried out a genome-wide association study using a general linear model (GLM) analysis on three separate cohorts, followed by meta-analysis and using a mixed linear model analysis on all samples. The variations in response explained by each single nucleotide polymo","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jan","modification":"2026-04-13T08:03:42.886Z","creation":"2026-04-07T13:29:19.951Z"},"accession":"S-EPMC5152628","cross_references":{"pubmed":["27846195"],"doi":["10.1097/FPC.0000000000000250"]}}