biostudies-literatureUnknown27(1)Li Q<h4>Objective</h4>Clinical response to the atypical antipsychotic paliperidone is known to vary among schizophrenic patients. We carried out a genome-wide association study to identify common genetic variants predictive of paliperidone efficacy.<h4>Methods</h4>We leveraged a collection of 1390 samples from individuals of European ancestry enrolled in 12 clinical studies investigating the efficacy of the extended-release tablet paliperidone ER (n1=490) and the once-monthly injection paliperidone palmitate (n2=550 and n3=350). We carried out a genome-wide association study using a general linear model (GLM) analysis on three separate cohorts, followed by meta-analysis and using a mixed linear model analysis on all samples. The variations in response explained by each single nucleotide polymoPharmacogenetics and genomics7-18https://www.ebi.ac.uk/biostudies/studies/S-EPMC5152628biostudies-literatureGenome-wide association study of paliperidone efficacy.PMC5152628Savitz ASchork NJFu DJAlphs LCohen NLibiger OLi QGopal SWineinger NEfalseGenome-wide association study of paliperidone efficacy.<h4>Objective</h4>Clinical response to the atypical antipsychotic paliperidone is known to vary among schizophrenic patients. We carried out a genome-wide association study to identify common genetic variants predictive of paliperidone efficacy.<h4>Methods</h4>We leveraged a collection of 1390 samples from individuals of European ancestry enrolled in 12 clinical studies investigating the efficacy of the extended-release tablet paliperidone ER (n1=490) and the once-monthly injection paliperidone palmitate (n2=550 and n3=350). We carried out a genome-wide association study using a general linear model (GLM) analysis on three separate cohorts, followed by meta-analysis and using a mixed linear model analysis on all samples. The variations in response explained by each single nucleotide polymo2017-01-01T00:00:00Z2017 Jan2026-04-13T08:03:42.886Z2026-04-07T13:29:19.951ZS-EPMC51526282784619510.1097/FPC.0000000000000250