{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Boldogh IR"],"funding":["NIGMS NIH HHS"],"pagination":["3994-4002"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC515334"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(9)"],"pubmed_abstract":["Two actin-dependent force generators contribute to mitochondrial inheritance: Arp2/3 complex and the myosin V Myo2p (together with its Rab-like binding partner Ypt11p). We found that deletion of YPT11, reduction of the length of the Myo2p lever arm (myo2-Delta6IQ), or deletion of MYO4 (the other yeast myosin V), had no effect on mitochondrial morphology, colocalization of mitochondria with actin cables, or the velocity of bud-directed mitochondrial movement. In contrast, retention of mitochondria in the bud was compromised in YPT11 and MYO2 mutants. Retention of mitochondria in the bud tip of wild-type cells results in a 60% decrease in mitochondrial movement in buds compared with mother cells. In ypt11Delta mutants, however, the level of mitochondrial motility in buds was similar to that "],"journal":["Molecular biology of the cell"],"pubmed_title":["A type V myosin (Myo2p) and a Rab-like G-protein (Ypt11p) are required for retention of newly inherited mitochondria in yeast cells during cell division."],"pmcid":["PMC515334"],"funding_grant_id":["GM-45735","GM-66037","R01 GM045735"],"pubmed_authors":["Boldogh IR","Yang HC","Pon LA","Ramcharan SL"],"additional_accession":[]},"is_claimable":false,"name":"A type V myosin (Myo2p) and a Rab-like G-protein (Ypt11p) are required for retention of newly inherited mitochondria in yeast cells during cell division.","description":"Two actin-dependent force generators contribute to mitochondrial inheritance: Arp2/3 complex and the myosin V Myo2p (together with its Rab-like binding partner Ypt11p). We found that deletion of YPT11, reduction of the length of the Myo2p lever arm (myo2-Delta6IQ), or deletion of MYO4 (the other yeast myosin V), had no effect on mitochondrial morphology, colocalization of mitochondria with actin cables, or the velocity of bud-directed mitochondrial movement. In contrast, retention of mitochondria in the bud was compromised in YPT11 and MYO2 mutants. Retention of mitochondria in the bud tip of wild-type cells results in a 60% decrease in mitochondrial movement in buds compared with mother cells. In ypt11Delta mutants, however, the level of mitochondrial motility in buds was similar to that ","dates":{"release":"2004-01-01T00:00:00Z","publication":"2004 Sep","modification":"2025-04-05T15:27:12.234Z","creation":"2019-03-27T00:50:45Z"},"accession":"S-EPMC515334","cross_references":{"pubmed":["15215313"],"doi":["10.1091/mbc.e04-01-0053"]}}