{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Heink S"],"funding":["European Research Council","NIAID NIH HHS"],"pagination":["74-85"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5164931"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["The cellular sources of interleukin 6 (IL-6) that are relevant for differentiation of the T<sub>H</sub>17 subset of helper T cells remain unclear. Here we used a novel strategy for the conditional deletion of distinct IL-6-producing cell types to show that dendritic cells (DCs) positive for the signaling regulator Sirpα were essential for the generation of pathogenic T<sub>H</sub>17 cells. Using their IL-6 receptor α-chain (IL-6Rα), Sirpα<sup>+</sup> DCs trans-presented IL-6 to T cells during the process of cognate interaction. While ambient IL-6 was sufficient to suppress the induction of expression of the transcription factor Foxp3 in T cells, trans-presentation of IL-6 by DC-bound IL-6Rα (called 'IL-6 cluster signaling' here) was needed to prevent premature induction of interferon-γ (IF"],"journal":["Nature immunology"],"pubmed_title":["Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T&lt;sub&gt;H&lt;/sub&gt;17 cells."],"pmcid":["PMC5164931"],"funding_grant_id":["647215","R21 AI124735"],"pubmed_authors":["Oukka M","Bartsch HS","Regen T","Blum H","Misgeld T","Moller-Hackbarth K","Husterer V","Rose-John S","Heink S","Schmidt-Supprian M","Waisman A","Wunderlich TF","Garbers C","Hidalgo J","Gasperi C","Hemmer B","Sotlar K","Herwerth M","Korn T","Croxford AL","Krebs S","Aly L","Yogev N"],"additional_accession":[]},"is_claimable":false,"name":"Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T&lt;sub&gt;H&lt;/sub&gt;17 cells.","description":"The cellular sources of interleukin 6 (IL-6) that are relevant for differentiation of the T<sub>H</sub>17 subset of helper T cells remain unclear. Here we used a novel strategy for the conditional deletion of distinct IL-6-producing cell types to show that dendritic cells (DCs) positive for the signaling regulator Sirpα were essential for the generation of pathogenic T<sub>H</sub>17 cells. Using their IL-6 receptor α-chain (IL-6Rα), Sirpα<sup>+</sup> DCs trans-presented IL-6 to T cells during the process of cognate interaction. While ambient IL-6 was sufficient to suppress the induction of expression of the transcription factor Foxp3 in T cells, trans-presentation of IL-6 by DC-bound IL-6Rα (called 'IL-6 cluster signaling' here) was needed to prevent premature induction of interferon-γ (IF","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jan","modification":"2026-04-28T23:52:50.541Z","creation":"2019-03-27T02:31:47Z"},"accession":"S-EPMC5164931","cross_references":{"pubmed":["27893700"],"doi":["10.1038/ni.3632"]}}