{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jensen SM"],"funding":["NIH HHS","NIGMS NIH HHS"],"pagination":["2216-2219"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5170875"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(23)"],"pubmed_abstract":["Chemical crosslinking is a versatile tool for the examination of biochemical interactions, in particular host-pathogen interactions. We report the critical first step toward the goal of probing these interactions by the synthesis and use of a new heterobifunctional crosslinker containing a triazabutadiene scaffold. The triazabutadiene is stable to protein conjugation and liberates a reactive aryl diazonium species upon irradiation with 350 nm light. We highlight the use of this technology by modifying the surface of several proteins, including the dengue virus envelope protein."],"journal":["Chembiochem : a European journal of chemical biology"],"pubmed_title":["Light-Activated Triazabutadienes for the Modification of a Viral Surface."],"pmcid":["PMC5170875"],"funding_grant_id":["T32 GM008804","S10 OD013237"],"pubmed_authors":["Jewett JC","Kimani FW","Jensen SM"],"additional_accession":[]},"is_claimable":false,"name":"Light-Activated Triazabutadienes for the Modification of a Viral Surface.","description":"Chemical crosslinking is a versatile tool for the examination of biochemical interactions, in particular host-pathogen interactions. We report the critical first step toward the goal of probing these interactions by the synthesis and use of a new heterobifunctional crosslinker containing a triazabutadiene scaffold. The triazabutadiene is stable to protein conjugation and liberates a reactive aryl diazonium species upon irradiation with 350 nm light. We highlight the use of this technology by modifying the surface of several proteins, including the dengue virus envelope protein.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Dec","modification":"2026-04-16T17:20:09.292Z","creation":"2019-03-27T02:31:58Z"},"accession":"S-EPMC5170875","cross_references":{"pubmed":["27647786"],"doi":["10.1002/cbic.201600508"]}}