{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hettiarachchi N"],"funding":["Grants-in-Aid for Scientific Research from Ministry of Education, Culture, Sports, Science and Technology, Japan"],"pagination":["3377-3392"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5203776"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(11)"],"pubmed_abstract":["Conserved non-coding sequences (CNSs) of Eukaryotes are known to be significantly enriched in regulatory sequences. CNSs of diverse lineages follow different patterns in abundance, sequence composition, and location. Here, we report a thorough analysis of CNSs in diverse groups of Eukaryotes with respect to GC content heterogeneity. We examined 24 fungi, 19 invertebrates, and 12 non-mammalian vertebrates so as to find lineage specific features of CNSs. We found that fungi and invertebrate CNSs are predominantly GC rich as in plants we previously observed, whereas vertebrate CNSs are GC poor. This result suggests that the CNS GC content transition occurred from the ancestral GC rich state of Eukaryotes to GC poor in the vertebrate lineage due to the enrollment of GC poor transcription facto"],"journal":["Genome biology and evolution"],"pubmed_title":["GC Content Heterogeneity Transition of Conserved Noncoding Sequences Occurred at the Emergence of Vertebrates."],"pmcid":["PMC5203776"],"funding_grant_id":["26251040"],"pubmed_authors":["Hettiarachchi N","Saitou N"],"additional_accession":[]},"is_claimable":false,"name":"GC Content Heterogeneity Transition of Conserved Noncoding Sequences Occurred at the Emergence of Vertebrates.","description":"Conserved non-coding sequences (CNSs) of Eukaryotes are known to be significantly enriched in regulatory sequences. CNSs of diverse lineages follow different patterns in abundance, sequence composition, and location. Here, we report a thorough analysis of CNSs in diverse groups of Eukaryotes with respect to GC content heterogeneity. We examined 24 fungi, 19 invertebrates, and 12 non-mammalian vertebrates so as to find lineage specific features of CNSs. We found that fungi and invertebrate CNSs are predominantly GC rich as in plants we previously observed, whereas vertebrate CNSs are GC poor. This result suggests that the CNS GC content transition occurred from the ancestral GC rich state of Eukaryotes to GC poor in the vertebrate lineage due to the enrollment of GC poor transcription facto","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Dec","modification":"2025-04-20T00:38:22.113Z","creation":"2025-04-20T00:38:22.113Z"},"accession":"S-EPMC5203776","cross_references":{"pubmed":["28040773"],"doi":["10.1093/gbe/evw231"]}}