biostudies-literatureCondit RCIntramural CDC HHS6610-6616https://www.ebi.ac.uk/biostudies/studies/S-EPMC5204448biostudies-literatureUnknown34(51)In 2003 and 2013, the World Health Organization convened informal consultations on characterization and quality aspects of vaccines based on live virus vectors. In the resulting reports, one of several issues raised for future study was the potential for recombination of virus-vectored vaccines with wild type pathogenic virus strains. This paper presents an assessment of this issue formulated by the Brighton Collaboration. To provide an appropriate context for understanding the potential for recombination of virus-vectored vaccines, we review briefly the current status of virus-vectored vaccines, mechanisms of recombination between viruses, experience with recombination involving live attenuated vaccines in the field, and concerns raised previously in the literature regarding recombinationVaccineUnique safety issues associated with virus-vectored vaccines: Potential for and theoretical consequences of recombination with wild type virus strains.PMC5204448CC999999Kim DMichael Hendry RRobertson JSWilliamson ALSheets RMonath TPGurwith MExcler JLChen RTSeligman SJBrighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG)Mac LMCondit RCBok KSingh VfalseUnique safety issues associated with virus-vectored vaccines: Potential for and theoretical consequences of recombination with wild type virus strains.In 2003 and 2013, the World Health Organization convened informal consultations on characterization and quality aspects of vaccines based on live virus vectors. In the resulting reports, one of several issues raised for future study was the potential for recombination of virus-vectored vaccines with wild type pathogenic virus strains. This paper presents an assessment of this issue formulated by the Brighton Collaboration. To provide an appropriate context for understanding the potential for recombination of virus-vectored vaccines, we review briefly the current status of virus-vectored vaccines, mechanisms of recombination between viruses, experience with recombination involving live attenuated vaccines in the field, and concerns raised previously in the literature regarding recombination2016-01-01T00:00:00Z2016 Dec2026-05-29T18:01:54.614Z2020-05-22T18:04:24ZS-EPMC52044482734630310.1016/j.vaccine.2016.04.060