biostudies-literatureUnknown7Yu TYGastric atrophy results in lower plasma ghrelin, higher gastrin secretion, a change in gut microbiota, and altered dietary nutrient absorption, which may be associated with the incidence of diabetes. Helicobacter pylori (H. pylori) infection is a major cause of gastric atrophy and is associated with diabetes in some reports. Since there is no study which investigates the impact of gastric atrophy on diabetes, we conduct a prospective cohort study to examine the relationship between H. pylori infection, gastric atrophy, and incident diabetes. In this study, subjects with gastric atrophy had a lower risk of incident diabetes, compared to those without gastric atrophy. The extent of gastric atrophy, measured by serum pepsinogen (PG) I/II ratio, was correlated with age, H. pylori IgG titer, HOScientific reports39777https://www.ebi.ac.uk/biostudies/studies/S-EPMC5206635biostudies-literatureThe Impact of Gastric Atrophy on the Incidence of Diabetes.PMC5206635Chuang LMHua CHLi HYHsiao CHYu TYHsu YWWu MSLiou JMWei JNLee MKKuo CHLin MSShih SRHsein YCfalseThe Impact of Gastric Atrophy on the Incidence of Diabetes.Gastric atrophy results in lower plasma ghrelin, higher gastrin secretion, a change in gut microbiota, and altered dietary nutrient absorption, which may be associated with the incidence of diabetes. Helicobacter pylori (H. pylori) infection is a major cause of gastric atrophy and is associated with diabetes in some reports. Since there is no study which investigates the impact of gastric atrophy on diabetes, we conduct a prospective cohort study to examine the relationship between H. pylori infection, gastric atrophy, and incident diabetes. In this study, subjects with gastric atrophy had a lower risk of incident diabetes, compared to those without gastric atrophy. The extent of gastric atrophy, measured by serum pepsinogen (PG) I/II ratio, was correlated with age, H. pylori IgG titer, HO2017-01-01T00:00:00Z2017 Jan2025-06-01T00:57:57.316Z2025-06-01T00:57:57.316ZS-EPMC52066352804507910.1038/srep39777