{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wagner CL"],"funding":["NICHD NIH HHS","NCATS NIH HHS","NCRR NIH HHS","NCI NIH HHS"],"pagination":["245-51"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5215876"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["155(Pt B)"],"pubmed_abstract":["Background
Two vitamin D pregnancy supplementation trials were recently undertaken in South Carolina: The NICHD (n=346) and Thrasher Research Fund (TRF, n=163) studies. The findings suggest increased dosages of supplemental vitamin D were associated with improved health outcomes of both mother and newborn, including risk of preterm birth (<37 weeks gestation). How that risk was associated with 25(OH)D serum concentration, a better indicator of vitamin D status than dosage, by race/ethnic group and the potential impact in the community was not previously explored. While a recent IOM report suggested a concentration of 20 ng/mL should be targeted, more recent work suggests optimal conversion of 25(OH)D-1,25(OH)2D takes place at 40 ng/mL in pregnant women.Objective
Post-hoc an"],"journal":["The Journal of steroid biochemistry and molecular biology"],"pubmed_title":["Post-hoc analysis of vitamin D status and reduced risk of preterm birth in two vitamin D pregnancy cohorts compared with South Carolina March of Dimes 2009-2011 rates."],"pmcid":["PMC5215876"],"funding_grant_id":["UL1 TR001450","UL1 RR029882","UL1 TR000062","P30 CA016672","R01HD47511","M01 RR001070","R01 HD047511","R01 HD043921","RR01070"],"pubmed_authors":["McDonnell S","Hamilton SA","Wagner CL","Baggerly C","French CB","Hollis BW","Baggerly KA","Baggerly L"],"additional_accession":[]},"is_claimable":false,"name":"Post-hoc analysis of vitamin D status and reduced risk of preterm birth in two vitamin D pregnancy cohorts compared with South Carolina March of Dimes 2009-2011 rates.","description":"Background
Two vitamin D pregnancy supplementation trials were recently undertaken in South Carolina: The NICHD (n=346) and Thrasher Research Fund (TRF, n=163) studies. The findings suggest increased dosages of supplemental vitamin D were associated with improved health outcomes of both mother and newborn, including risk of preterm birth (<37 weeks gestation). How that risk was associated with 25(OH)D serum concentration, a better indicator of vitamin D status than dosage, by race/ethnic group and the potential impact in the community was not previously explored. While a recent IOM report suggested a concentration of 20 ng/mL should be targeted, more recent work suggests optimal conversion of 25(OH)D-1,25(OH)2D takes place at 40 ng/mL in pregnant women.Objective
Post-hoc an","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2025-04-04T09:02:46.047Z","creation":"2019-03-27T02:33:18Z"},"accession":"S-EPMC5215876","cross_references":{"pubmed":["26554936"],"doi":["10.1016/j.jsbmb.2015.10.022"]}}