biostudies-literatureWagner CLNICHD NIH HHSNCATS NIH HHSNCRR NIH HHSNCI NIH HHS245-51https://www.ebi.ac.uk/biostudies/studies/S-EPMC5215876biostudies-literatureUnknown155(Pt B)<h4>Background</h4>Two vitamin D pregnancy supplementation trials were recently undertaken in South Carolina: The NICHD (n=346) and Thrasher Research Fund (TRF, n=163) studies. The findings suggest increased dosages of supplemental vitamin D were associated with improved health outcomes of both mother and newborn, including risk of preterm birth (<37 weeks gestation). How that risk was associated with 25(OH)D serum concentration, a better indicator of vitamin D status than dosage, by race/ethnic group and the potential impact in the community was not previously explored. While a recent IOM report suggested a concentration of 20 ng/mL should be targeted, more recent work suggests optimal conversion of 25(OH)D-1,25(OH)2D takes place at 40 ng/mL in pregnant women.<h4>Objective</h4>Post-hoc anThe Journal of steroid biochemistry and molecular biologyPost-hoc analysis of vitamin D status and reduced risk of preterm birth in two vitamin D pregnancy cohorts compared with South Carolina March of Dimes 2009-2011 rates.PMC5215876UL1 TR001450UL1 RR029882UL1 TR000062P30 CA016672R01HD47511M01 RR001070R01 HD047511R01 HD043921RR01070McDonnell SHamilton SAWagner CLBaggerly CFrench CBHollis BWBaggerly KABaggerly LfalsePost-hoc analysis of vitamin D status and reduced risk of preterm birth in two vitamin D pregnancy cohorts compared with South Carolina March of Dimes 2009-2011 rates.<h4>Background</h4>Two vitamin D pregnancy supplementation trials were recently undertaken in South Carolina: The NICHD (n=346) and Thrasher Research Fund (TRF, n=163) studies. The findings suggest increased dosages of supplemental vitamin D were associated with improved health outcomes of both mother and newborn, including risk of preterm birth (<37 weeks gestation). How that risk was associated with 25(OH)D serum concentration, a better indicator of vitamin D status than dosage, by race/ethnic group and the potential impact in the community was not previously explored. While a recent IOM report suggested a concentration of 20 ng/mL should be targeted, more recent work suggests optimal conversion of 25(OH)D-1,25(OH)2D takes place at 40 ng/mL in pregnant women.<h4>Objective</h4>Post-hoc an2016-01-01T00:00:00Z2016 Jan2025-04-04T09:02:46.047Z2019-03-27T02:33:18ZS-EPMC52158762655493610.1016/j.jsbmb.2015.10.022