biostudies-literatureKumar MNIMHD NIH HHSNational Institute on Minority Health and Health DisparitiesNational Institute of General Medical SciencesNIGMS NIH HHSe0005262https://www.ebi.ac.uk/biostudies/studies/S-EPMC5215948biostudies-literatureUnknown10(12)Zika virus (ZIKV) is an emerging mosquito-borne pathogen. ZIKV infection is linked to the development of severe fetal abnormalities that include spontaneous abortion, stillbirth, hydranencephaly, and microcephaly. ZIKV outbreaks have been recorded in the United States. We recently demonstrated the first congenital ZIKV infection in the United States. In this study, we investigated archived blood samples from six mothers who gave birth to babies with microcephaly and 12 mothers who gave birth to healthy babies in Hawaii between 2009 and 2012. We tested maternal blood for the presence of ZIKV IgM and IgG antibodies using commercially available human ZIKV IgM and IgG ELISA kits. Blood from one mother who delivered babies with microcephaly tested positive for ZIKV IgM antibody (16.6%) and blooPLoS neglected tropical diseasesPrevalence of Antibodies to Zika Virus in Mothers from Hawaii Who Delivered Babies with and without Microcephaly between 2009-2012.PMC5215948P30 GM114737P30GM114737G12 MD007601U54MD007584U54 MD007584G12MD007601Lim EAstern JStokes AJKumar MNerurkar VRChing LMelish MfalsePrevalence of Antibodies to Zika Virus in Mothers from Hawaii Who Delivered Babies with and without Microcephaly between 2009-2012.Zika virus (ZIKV) is an emerging mosquito-borne pathogen. ZIKV infection is linked to the development of severe fetal abnormalities that include spontaneous abortion, stillbirth, hydranencephaly, and microcephaly. ZIKV outbreaks have been recorded in the United States. We recently demonstrated the first congenital ZIKV infection in the United States. In this study, we investigated archived blood samples from six mothers who gave birth to babies with microcephaly and 12 mothers who gave birth to healthy babies in Hawaii between 2009 and 2012. We tested maternal blood for the presence of ZIKV IgM and IgG antibodies using commercially available human ZIKV IgM and IgG ELISA kits. Blood from one mother who delivered babies with microcephaly tested positive for ZIKV IgM antibody (16.6%) and bloo2016-01-01T00:00:00Z2016 Dec2025-04-04T09:02:59.17Z2019-03-26T22:45:18ZS-EPMC52159482799754710.1371/journal.pntd.0005262