{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":44,"searchCount":0},"additional":{"omics_type":["Unknown"],"volume":["7(30)"],"submitter":["Sablin MP"],"pubmed_abstract":["<h4>Background</h4>We aimed at identifying druggable molecular alterations at the RNA level from untreated HNSCC patients, and assessing their prognostic significance.<h4>Methods</h4>We retrieved 96 HNSCC patients who underwent primary surgery. Real-time quantitative RT-PCR was used to analyze a panel of 42 genes coding for major druggable proteins. Univariate and multivariate analyses were performed to assess the prognostic significance of overexpressed genes.<h4>Results</h4>Median age was 56 years [35-78]. Most of patients were men (80%) with a history of alcohol (70.4%) and/or tobacco consumption (72.5%). Twelve patients (12%) were HPV-positive. Most significantly overexpressed genes involved cell cycle regulation (CCND1 [27%], CDK6 [21%]), tyrosine kinase receptors (MET [18%], EGFR [14%]), angiogenesis (PGF [301%], VEGFA [14%]), and immune system (PDL1/CD274 [28%]). PIK3CA expression was an independent prognostic marker, associated with shorter disease-free survival.<h4>Conclusions</h4>We identified druggable overexpressed genes associated with a poor outcome that might be of interest for personalizing treatment of HNSCC patients."],"journal":["Oncotarget"],"pagination":["47418-47430"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5216951"],"repository":["biostudies-literature"],"pubmed_title":["Identification of new candidate therapeutic target genes in head and neck squamous cell carcinomas."],"pmcid":["PMC5216951"],"pubmed_authors":["Sastre-Garau X","Mariani O","Caly M","Rodriguez J","Girod A","Kamal M","Lappartient E","Vacher S","Sablin MP","Hoffmann C","Berger F","Chemlali W","Ouafi L","Bieche I","Klijanienko J","Jouffroy T","Calugaru V","Le Tourneau C","Lidereau R","Dubot C"],"view_count":["44"],"additional_accession":[]},"is_claimable":false,"name":"Identification of new candidate therapeutic target genes in head and neck squamous cell carcinomas.","description":"<h4>Background</h4>We aimed at identifying druggable molecular alterations at the RNA level from untreated HNSCC patients, and assessing their prognostic significance.<h4>Methods</h4>We retrieved 96 HNSCC patients who underwent primary surgery. Real-time quantitative RT-PCR was used to analyze a panel of 42 genes coding for major druggable proteins. Univariate and multivariate analyses were performed to assess the prognostic significance of overexpressed genes.<h4>Results</h4>Median age was 56 years [35-78]. Most of patients were men (80%) with a history of alcohol (70.4%) and/or tobacco consumption (72.5%). Twelve patients (12%) were HPV-positive. Most significantly overexpressed genes involved cell cycle regulation (CCND1 [27%], CDK6 [21%]), tyrosine kinase receptors (MET [18%], EGFR [14%]), angiogenesis (PGF [301%], VEGFA [14%]), and immune system (PDL1/CD274 [28%]). PIK3CA expression was an independent prognostic marker, associated with shorter disease-free survival.<h4>Conclusions</h4>We identified druggable overexpressed genes associated with a poor outcome that might be of interest for personalizing treatment of HNSCC patients.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jul","modification":"2024-11-20T10:06:50.129Z","creation":"2019-03-27T02:33:24Z"},"accession":"S-EPMC5216951","cross_references":{"pubmed":["27329726"],"doi":["10.18632/oncotarget.10163"]}}