{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lateef Z"],"funding":["Health Research Council of New Zealand"],"pagination":["39"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5217272"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["<h4>Background</h4>The GII.4 Sydney 2012 strain of human norovirus (HuNoV) is a pandemic strain that is responsible for the majority of norovirus outbreaks in healthcare settings. The function of the non-structural (NS)1-2 protein from HuNoV is unknown.<h4>Results</h4>In silico analysis of human norovirus NS1-2 protein showed that it shares features with the murine NS1-2 protein, including a disordered region, a transmembrane domain and H-box and NC sequence motifs. The proteins also contain caspase cleavage and phosphorylation sites, indicating that processing and phosphorylation may be a conserved feature of norovirus NS1-2 proteins. In this study, RNA transcripts of human and murine norovirus full-length and the disordered region of NS1-2 were transfected into monocytes, and next genera"],"journal":["BMC genomics"],"pubmed_title":["Transcriptomic analysis of human norovirus NS1-2 protein highlights a multifunctional role in murine monocytes."],"pmcid":["PMC5217272"],"funding_grant_id":["12-057 Career Development Award"],"pubmed_authors":["Baker ES","Ward VK","Gimenez G","Lateef Z"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic analysis of human norovirus NS1-2 protein highlights a multifunctional role in murine monocytes.","description":"<h4>Background</h4>The GII.4 Sydney 2012 strain of human norovirus (HuNoV) is a pandemic strain that is responsible for the majority of norovirus outbreaks in healthcare settings. The function of the non-structural (NS)1-2 protein from HuNoV is unknown.<h4>Results</h4>In silico analysis of human norovirus NS1-2 protein showed that it shares features with the murine NS1-2 protein, including a disordered region, a transmembrane domain and H-box and NC sequence motifs. The proteins also contain caspase cleavage and phosphorylation sites, indicating that processing and phosphorylation may be a conserved feature of norovirus NS1-2 proteins. In this study, RNA transcripts of human and murine norovirus full-length and the disordered region of NS1-2 were transfected into monocytes, and next genera","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jan","modification":"2026-06-10T05:43:32.76Z","creation":"2019-06-06T16:50:15Z"},"accession":"S-EPMC5217272","cross_references":{"pubmed":["28056773"],"doi":["10.1186/s12864-016-3417-4"]}}