{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Tan JK"],"pubmed_abstract":["Development of lymphoid tissue is determined by interactions between stromal lymphoid tissue organiser (LTo) and hematopoietic lymphoid tissue inducer (LTi) cells. A failure for LTo to receive appropriate activating signals during embryogenesis through lymphotoxin engagement leads to a complete cessation of lymph node (LN) and Peyer's patch development, identifying LTo as a key stromal population for lymphoid tissue organogenesis. However, little is known about the equivalent stromal cells that induce spleen development. Here, by dissociating neonatal murine spleen stromal tissue for re-aggregation and transplant into adult mouse recipients, we have identified a MAdCAM-1<sup>+</sup>CD31<sup>+</sup>CD201<sup>+</sup> spleen stromal organizer cell-type critical for new tissue formation. This "],"journal":["Scientific reports"],"pagination":["40401"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5220291"],"repository":["biostudies-literature"],"pubmed_title":["Stromal Cell Subsets Directing Neonatal Spleen Regeneration."],"pmcid":["PMC5220291"],"pubmed_authors":["Tan JK","Watanabe T"],"additional_accession":[]},"is_claimable":false,"name":"Stromal Cell Subsets Directing Neonatal Spleen Regeneration.","description":"Development of lymphoid tissue is determined by interactions between stromal lymphoid tissue organiser (LTo) and hematopoietic lymphoid tissue inducer (LTi) cells. A failure for LTo to receive appropriate activating signals during embryogenesis through lymphotoxin engagement leads to a complete cessation of lymph node (LN) and Peyer's patch development, identifying LTo as a key stromal population for lymphoid tissue organogenesis. However, little is known about the equivalent stromal cells that induce spleen development. Here, by dissociating neonatal murine spleen stromal tissue for re-aggregation and transplant into adult mouse recipients, we have identified a MAdCAM-1<sup>+</sup>CD31<sup>+</sup>CD201<sup>+</sup> spleen stromal organizer cell-type critical for new tissue formation. This ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jan","modification":"2025-04-26T13:40:29.204Z","creation":"2019-03-27T02:33:36Z"},"accession":"S-EPMC5220291","cross_references":{"pubmed":["28067323"],"doi":["10.1038/srep40401"]}}