{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(6)"],"submitter":["Khaghanzadeh N"],"pubmed_abstract":["Umbelliprenin (Umb), a natural coumarin, has demonstrated anti-tumor activities, both <i>in vitro</i> and particularly <i>in vivo</i>, in several types of cancer, including lung cancer. The present study aimed to identify molecular targets of Umb using a high-throughput approach. Lung cancer cell lines, QU-DB (large-cell lung carcinoma) and A549 (adenocarcinoma), were treated with Umb. Differentially-expressed proteins were identified using two-dimensional electrophoresis coupled to mass spectrometry. In the QU-DB cells, differential expression of proteins, including downregulation of the tumorigenic protein heat shock protein 90 kDa and upregulation of the potential anti-tumor proteins Nipsnap1 and glycine-tRNA ligase (GRS), suggested that Umb is a strong anti-tumor compound. In the A549 "],"journal":["Oncology letters"],"pagination":["5295-5302"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5228441"],"repository":["biostudies-literature"],"pubmed_title":["Immune-associated proteins with potential <i>in vivo</i> anti-tumor activities are upregulated in lung cancer cells treated with umbelliprenin: A proteomic approach."],"pmcid":["PMC5228441"],"pubmed_authors":["Khaghanzadeh N","Kuramitsu Y","Ghaderi A","Mojtahedi Z","Nakamura K"],"additional_accession":[]},"is_claimable":false,"name":"Immune-associated proteins with potential <i>in vivo</i> anti-tumor activities are upregulated in lung cancer cells treated with umbelliprenin: A proteomic approach.","description":"Umbelliprenin (Umb), a natural coumarin, has demonstrated anti-tumor activities, both <i>in vitro</i> and particularly <i>in vivo</i>, in several types of cancer, including lung cancer. The present study aimed to identify molecular targets of Umb using a high-throughput approach. Lung cancer cell lines, QU-DB (large-cell lung carcinoma) and A549 (adenocarcinoma), were treated with Umb. Differentially-expressed proteins were identified using two-dimensional electrophoresis coupled to mass spectrometry. In the QU-DB cells, differential expression of proteins, including downregulation of the tumorigenic protein heat shock protein 90 kDa and upregulation of the potential anti-tumor proteins Nipsnap1 and glycine-tRNA ligase (GRS), suggested that Umb is a strong anti-tumor compound. In the A549 ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Dec","modification":"2025-04-27T00:54:03.859Z","creation":"2021-02-20T07:28:28Z"},"accession":"S-EPMC5228441","cross_references":{"pubmed":["28105238"],"doi":["10.3892/ol.2016.5352"]}}